Multi-scale models for the optimization of batch bioreactors
Process models play an important role in the bioreactor design, optimisation and control. In previous work, the bioreactor models have mainly been developed by considering the microbial kinetics and the reactor environmental conditions with the assumption that the ideal mixing occurs inside the reac...
| Main Authors: | , , |
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| Format: | Journal Article |
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Pergamon
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/22901 |
| _version_ | 1848751002522484736 |
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| author | Liew, Emily Nandong, Jobrun Samyudia, Yudi |
| author_facet | Liew, Emily Nandong, Jobrun Samyudia, Yudi |
| author_sort | Liew, Emily |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Process models play an important role in the bioreactor design, optimisation and control. In previous work, the bioreactor models have mainly been developed by considering the microbial kinetics and the reactor environmental conditions with the assumption that the ideal mixing occurs inside the reactor. This assumption is relatively difficult to meet in the practical applications. In this paper, we propose a new approach to the bioreactor modelling by expanding the so-called Herbert’s Microbial Kinetics (HMK) model so that the developed models are able to incorporate the mixing effects via the inclusion of the aeration rate and stirrer speed into the microbial kinetics. The expanded models of Herbert’s microbial kinetics allow us to optimize the bioreactor’s performances with respects to the aeration rate and stirrer speed as the decision variables, where this optimisation is not possible using the original HMK model of microbial kinetics. Simulation and experimental studies on a batch ethanolic fermentation demonstrates the use of the expanded HMK models for the optimisation of bioreactor’s performances. It is shown that the integration of the expanded HMK model with the Computational Fluid Dynamics (CFD) model of mixing, which we call it as a Kinetics Multi-Scale (KMS) model, is able to predict the experimental values of yield and productivity of the batch fermentation process accurately (with less than 5% errors). |
| first_indexed | 2025-11-14T07:45:48Z |
| format | Journal Article |
| id | curtin-20.500.11937-22901 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:45:48Z |
| publishDate | 2013 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-229012019-02-19T04:26:27Z Multi-scale models for the optimization of batch bioreactors Liew, Emily Nandong, Jobrun Samyudia, Yudi Fermentation Bioreactor Kinetics CFD Optimization Modelling Process models play an important role in the bioreactor design, optimisation and control. In previous work, the bioreactor models have mainly been developed by considering the microbial kinetics and the reactor environmental conditions with the assumption that the ideal mixing occurs inside the reactor. This assumption is relatively difficult to meet in the practical applications. In this paper, we propose a new approach to the bioreactor modelling by expanding the so-called Herbert’s Microbial Kinetics (HMK) model so that the developed models are able to incorporate the mixing effects via the inclusion of the aeration rate and stirrer speed into the microbial kinetics. The expanded models of Herbert’s microbial kinetics allow us to optimize the bioreactor’s performances with respects to the aeration rate and stirrer speed as the decision variables, where this optimisation is not possible using the original HMK model of microbial kinetics. Simulation and experimental studies on a batch ethanolic fermentation demonstrates the use of the expanded HMK models for the optimisation of bioreactor’s performances. It is shown that the integration of the expanded HMK model with the Computational Fluid Dynamics (CFD) model of mixing, which we call it as a Kinetics Multi-Scale (KMS) model, is able to predict the experimental values of yield and productivity of the batch fermentation process accurately (with less than 5% errors). 2013 Journal Article http://hdl.handle.net/20.500.11937/22901 10.1016/j.ces.2013.03.036 Pergamon fulltext |
| spellingShingle | Fermentation Bioreactor Kinetics CFD Optimization Modelling Liew, Emily Nandong, Jobrun Samyudia, Yudi Multi-scale models for the optimization of batch bioreactors |
| title | Multi-scale models for the optimization of batch bioreactors |
| title_full | Multi-scale models for the optimization of batch bioreactors |
| title_fullStr | Multi-scale models for the optimization of batch bioreactors |
| title_full_unstemmed | Multi-scale models for the optimization of batch bioreactors |
| title_short | Multi-scale models for the optimization of batch bioreactors |
| title_sort | multi-scale models for the optimization of batch bioreactors |
| topic | Fermentation Bioreactor Kinetics CFD Optimization Modelling |
| url | http://hdl.handle.net/20.500.11937/22901 |