A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development

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A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development

Tissue factor pathway inhibitor (TFPI) is a critical anticoagulant protein present in endothelium and platelets. Mice lacking TFPI (Tfpi−/−) die in utero from disseminated intravascular coagulation. They are rescued by concomitant tissue factor (TF) deficiency, demonstrating that TFPI modulates TF f...

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Bibliographic Details
Main Authors:	Ellery, Paul, Maroney, S., Cooley, B., Luyendyk, J., Zogg, M., Weiler, H., Mast, A.
Format:	Journal Article
Published:	American Society of Hematology 2015
Online Access:	http://hdl.handle.net/20.500.11937/22776

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