Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children
Background Severe asthma is a frequent cause of hospital admission, especially among children. The main environmental triggers of airway inflammation in asthma are viruses and aeroallergens. These agents elicit reciprocal immune responses, characterised by production of T helper 1 and T helper 2 cyt...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier
2002
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| Online Access: | http://hdl.handle.net/20.500.11937/22722 |
| _version_ | 1848750949521162240 |
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| author | Morahan, G. Huang, D. Wu, M. Holt, B. White, G. Kendall, Garth Sly, Peter Holt, P. |
| author_facet | Morahan, G. Huang, D. Wu, M. Holt, B. White, G. Kendall, Garth Sly, Peter Holt, P. |
| author_sort | Morahan, G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background Severe asthma is a frequent cause of hospital admission, especially among children. The main environmental triggers of airway inflammation in asthma are viruses and aeroallergens. These agents elicit reciprocal immune responses, characterised by production of T helper 1 and T helper 2 cytokines, respectively. There is no genetic explanation for how hyper-responsiveness to these disparate environmental stimuli develops among individuals with asthma. Our aim was to assess relation between an IL12B promoter polymorphism and asthma. |
| first_indexed | 2025-11-14T07:44:57Z |
| format | Journal Article |
| id | curtin-20.500.11937-22722 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:44:57Z |
| publishDate | 2002 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-227222018-10-02T05:31:06Z Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children Morahan, G. Huang, D. Wu, M. Holt, B. White, G. Kendall, Garth Sly, Peter Holt, P. Background Severe asthma is a frequent cause of hospital admission, especially among children. The main environmental triggers of airway inflammation in asthma are viruses and aeroallergens. These agents elicit reciprocal immune responses, characterised by production of T helper 1 and T helper 2 cytokines, respectively. There is no genetic explanation for how hyper-responsiveness to these disparate environmental stimuli develops among individuals with asthma. Our aim was to assess relation between an IL12B promoter polymorphism and asthma. 2002 Journal Article http://hdl.handle.net/20.500.11937/22722 10.1016/S0140-6736(02)09676-9 Elsevier restricted |
| spellingShingle | Morahan, G. Huang, D. Wu, M. Holt, B. White, G. Kendall, Garth Sly, Peter Holt, P. Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children |
| title | Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children |
| title_full | Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children |
| title_fullStr | Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children |
| title_full_unstemmed | Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children |
| title_short | Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children |
| title_sort | association of il12b promoter polymorphism with severity of atopic and non-atopic asthma in children |
| url | http://hdl.handle.net/20.500.11937/22722 |