Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt
Mesenchymal stem cells (MSCs) are multipotent precursor cells originating from several adult connective tissues. MSCs possess the ability to self-renew and differentiate into several lineages, and are recognized by the expression of unique cell surface markers. Several lines of evidence suggest that...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/22581 |
| _version_ | 1848750910121967616 |
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| author | Visweswaran, Malini Pohl, Sebastian Arfuso, Frank Newsholme, Philip Dilley, R. Pervaiz, S. Dharmarajan, Arunasalam |
| author_facet | Visweswaran, Malini Pohl, Sebastian Arfuso, Frank Newsholme, Philip Dilley, R. Pervaiz, S. Dharmarajan, Arunasalam |
| author_sort | Visweswaran, Malini |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Mesenchymal stem cells (MSCs) are multipotent precursor cells originating from several adult connective tissues. MSCs possess the ability to self-renew and differentiate into several lineages, and are recognized by the expression of unique cell surface markers. Several lines of evidence suggest that various signal transduction pathways and their interplay regulate MSC differentiation. To that end, a critical player in regulating MSC differentiation is a group of proteins encoded by the Wnt gene family, which was previously known for influencing various stages of embryonic development and cell fate determination. As MSCs have gained significant clinical attention for their potential applications in regenerative medicine, it is imperative to unravel the mechanisms by which molecular regulators control differentiation of MSCs for designing cell-based therapeutics. It is rather coincidental that the functional outcome(s) of Wnt-induced signals share similarities with cellular redox-mediated networks from the standpoint of MSC biology. Furthermore, there is evidence for a crosstalk between Wnt and redox signalling, which begs the question whether Wnt-mediated differentiation signals involve the intermediary role of reactive oxygen species. In this review, we summarize the impact of Wnt signalling on multi-lineage differentiation of MSCs, and attempt to unravel the intricate interplay between Wnt and redox signals. |
| first_indexed | 2025-11-14T07:44:20Z |
| format | Journal Article |
| id | curtin-20.500.11937-22581 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:44:20Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-225812017-11-16T03:50:44Z Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt Visweswaran, Malini Pohl, Sebastian Arfuso, Frank Newsholme, Philip Dilley, R. Pervaiz, S. Dharmarajan, Arunasalam Mesenchymal stem cells (MSCs) are multipotent precursor cells originating from several adult connective tissues. MSCs possess the ability to self-renew and differentiate into several lineages, and are recognized by the expression of unique cell surface markers. Several lines of evidence suggest that various signal transduction pathways and their interplay regulate MSC differentiation. To that end, a critical player in regulating MSC differentiation is a group of proteins encoded by the Wnt gene family, which was previously known for influencing various stages of embryonic development and cell fate determination. As MSCs have gained significant clinical attention for their potential applications in regenerative medicine, it is imperative to unravel the mechanisms by which molecular regulators control differentiation of MSCs for designing cell-based therapeutics. It is rather coincidental that the functional outcome(s) of Wnt-induced signals share similarities with cellular redox-mediated networks from the standpoint of MSC biology. Furthermore, there is evidence for a crosstalk between Wnt and redox signalling, which begs the question whether Wnt-mediated differentiation signals involve the intermediary role of reactive oxygen species. In this review, we summarize the impact of Wnt signalling on multi-lineage differentiation of MSCs, and attempt to unravel the intricate interplay between Wnt and redox signals. 2015 Journal Article http://hdl.handle.net/20.500.11937/22581 10.1016/j.biocel.2015.09.008 fulltext |
| spellingShingle | Visweswaran, Malini Pohl, Sebastian Arfuso, Frank Newsholme, Philip Dilley, R. Pervaiz, S. Dharmarajan, Arunasalam Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt |
| title | Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt |
| title_full | Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt |
| title_fullStr | Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt |
| title_full_unstemmed | Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt |
| title_short | Multi-lineage differentiation of mesenchymal stem cells - To Wnt, or not Wnt |
| title_sort | multi-lineage differentiation of mesenchymal stem cells - to wnt, or not wnt |
| url | http://hdl.handle.net/20.500.11937/22581 |