Studies on the Effect of Aging and Mesothelioma on Dendritic Cell Subsets
Mesothelioma is a cancer that occurs in the elderly. Dendritic cells (DC) play a key role in generating immune responses. This thesis examined DCs in elderly mesothelioma patients and reports that numerical and functional defects due to aging were significantly amplified in mesothelioma patients. Wh...
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| Format: | Thesis |
| Language: | English |
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Curtin University
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/2236 |
| _version_ | 1848743897626312704 |
|---|---|
| author | Cornwall, Scott M.J. |
| author_facet | Cornwall, Scott M.J. |
| author_sort | Cornwall, Scott M.J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Mesothelioma is a cancer that occurs in the elderly. Dendritic cells (DC) play a key role in generating immune responses. This thesis examined DCs in elderly mesothelioma patients and reports that numerical and functional defects due to aging were significantly amplified in mesothelioma patients. Whilst CD40 stimulation recued the function of healthy elderly DCs it offered little benefit to mesothelioma DCs. Surgery improved mesothelioma DC function implying a window of opportunity for use of immunotherapies. |
| first_indexed | 2025-11-14T05:52:52Z |
| format | Thesis |
| id | curtin-20.500.11937-2236 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T05:52:52Z |
| publishDate | 2015 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-22362017-02-20T06:37:56Z Studies on the Effect of Aging and Mesothelioma on Dendritic Cell Subsets Cornwall, Scott M.J. Mesothelioma is a cancer that occurs in the elderly. Dendritic cells (DC) play a key role in generating immune responses. This thesis examined DCs in elderly mesothelioma patients and reports that numerical and functional defects due to aging were significantly amplified in mesothelioma patients. Whilst CD40 stimulation recued the function of healthy elderly DCs it offered little benefit to mesothelioma DCs. Surgery improved mesothelioma DC function implying a window of opportunity for use of immunotherapies. 2015 Thesis http://hdl.handle.net/20.500.11937/2236 en Curtin University fulltext |
| spellingShingle | Cornwall, Scott M.J. Studies on the Effect of Aging and Mesothelioma on Dendritic Cell Subsets |
| title | Studies on the Effect of Aging and Mesothelioma on Dendritic Cell Subsets |
| title_full | Studies on the Effect of Aging and Mesothelioma on Dendritic Cell Subsets |
| title_fullStr | Studies on the Effect of Aging and Mesothelioma on Dendritic Cell Subsets |
| title_full_unstemmed | Studies on the Effect of Aging and Mesothelioma on Dendritic Cell Subsets |
| title_short | Studies on the Effect of Aging and Mesothelioma on Dendritic Cell Subsets |
| title_sort | studies on the effect of aging and mesothelioma on dendritic cell subsets |
| url | http://hdl.handle.net/20.500.11937/2236 |