Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria
Pulmonary disease due to non-tuberculous mycobacteria (NTM) is caused by several species (particularly Mycobacterium avium, Mycobacterium intracellulare) that are abundant in the environment. Th1 cytokines such as interferon (IFN)-γ are important in the control of mycobacteria, but in vitro producti...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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Academic Press
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/22117 |
| _version_ | 1848750780771729408 |
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| author | Kim, K. Waterer, G. Thomson, R. Yang, I. Nashi, N. Tan, D. Price, Patricia |
| author_facet | Kim, K. Waterer, G. Thomson, R. Yang, I. Nashi, N. Tan, D. Price, Patricia |
| author_sort | Kim, K. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pulmonary disease due to non-tuberculous mycobacteria (NTM) is caused by several species (particularly Mycobacterium avium, Mycobacterium intracellulare) that are abundant in the environment. Th1 cytokines such as interferon (IFN)-γ are important in the control of mycobacteria, but in vitro production of IFN-γ is not deficient in adult patients with pulmonary NTM disease. Antibodies reactive with IFN-γ have been described in patients with disseminated NTM disease, but it is not clear whether they are common in pulmonary disease. Here we show that patients with pulmonary NTM have a higher level of anti-IFN-γ and anti-GM-CSF antibodies than healthy controls, although some controls also have high levels. Levels of anti-IFN-γ antibodies did not correlate with levels of total immunoglobulin. Longitudinal studies are required to determine whether anti-cytokine autoantibodies are consequence rather than a cause of pulmonary NTM disease. |
| first_indexed | 2025-11-14T07:42:17Z |
| format | Journal Article |
| id | curtin-20.500.11937-22117 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:42:17Z |
| publishDate | 2014 |
| publisher | Academic Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-221172017-09-13T13:52:24Z Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria Kim, K. Waterer, G. Thomson, R. Yang, I. Nashi, N. Tan, D. Price, Patricia Cytokine Autoantibody Interferon-? Pulmonary disease Non-tuberculous mycobacteria Pulmonary disease due to non-tuberculous mycobacteria (NTM) is caused by several species (particularly Mycobacterium avium, Mycobacterium intracellulare) that are abundant in the environment. Th1 cytokines such as interferon (IFN)-γ are important in the control of mycobacteria, but in vitro production of IFN-γ is not deficient in adult patients with pulmonary NTM disease. Antibodies reactive with IFN-γ have been described in patients with disseminated NTM disease, but it is not clear whether they are common in pulmonary disease. Here we show that patients with pulmonary NTM have a higher level of anti-IFN-γ and anti-GM-CSF antibodies than healthy controls, although some controls also have high levels. Levels of anti-IFN-γ antibodies did not correlate with levels of total immunoglobulin. Longitudinal studies are required to determine whether anti-cytokine autoantibodies are consequence rather than a cause of pulmonary NTM disease. 2014 Journal Article http://hdl.handle.net/20.500.11937/22117 10.1016/j.cyto.2014.01.005 Academic Press restricted |
| spellingShingle | Cytokine Autoantibody Interferon-? Pulmonary disease Non-tuberculous mycobacteria Kim, K. Waterer, G. Thomson, R. Yang, I. Nashi, N. Tan, D. Price, Patricia Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria |
| title | Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria |
| title_full | Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria |
| title_fullStr | Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria |
| title_full_unstemmed | Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria |
| title_short | Levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria |
| title_sort | levels of anti-cytokine antibodies may be elevated in patients with pulmonary disease associated with non-tuberculous mycobacteria |
| topic | Cytokine Autoantibody Interferon-? Pulmonary disease Non-tuberculous mycobacteria |
| url | http://hdl.handle.net/20.500.11937/22117 |