Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?

QR Code

Are macrophages, myeloid derived suppressor cells and neutrophils mediators of local suppression in healthy and cancerous tissues in aging hosts?

Lung cancer is one of the commonest cancers worldwide and the incidence of malignant mesothelioma, caused by asbestos, is growing to global epidemic proportions. Standard chemotherapy only extends life expectancy in both cancers by, at best, a few years thus there is an urgent need for new treatment...

Full description

Bibliographic Details
Main Authors:	Jackaman, Connie, Nelson, Delia
Format:	Journal Article
Published:	Elsevier 2013
Subjects:	Neutrophil Immunotherapy Chemotherapy Aging Macrophage Myeloid-derived suppressor cell Cancer
Online Access:	http://hdl.handle.net/20.500.11937/21896

Similar Items

IL-2/CD40-activated macrophages rescue age and tumor-induced T cell dysfunction in elderly mice
by: Jackaman, Connie, et al.
Published: (2014)

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice
by: Jackaman, Connie, et al.
Published: (2013)

Effect of Mannose Receptor (MR)-binding polymers on human macrophages
by: de Medeiros Costa, Diego
Published: (2019)

Efficacy of dendritic cell-based vaccine on acute myeloid leukaemia in a murine model
by: Ng, Wei Yi
Published: (2013)

Kinetics of chemokine-glycosaminoglycan interactions control neutrophil migration into the airspaces of the lungs
by: Tanino, Y., et al.
Published: (2010)

Aging and cancer: The role of macrophages and neutrophils
by: Jackaman, Connie, et al.
Published: (2017)

Characterisation of Myeloid, Lymphiod and Erythroid Cell Lineages in Myelodysplastics Syndrome Using Flow Cytometry
by: Broojerdi, Mohadese Hashem
Published: (2011)

Microarray-based genomic analysis identifies germline and somatic copy number variants and loss of heterozygosity in acute myeloid leukaemia
by: Ambayya @ Ampiah, A Angeli
Published: (2015)

Regulation of ige-mediated mast cell degranulation in allergy by geranyl acetophenone
by: Tan, Ji Wei
Published: (2017)

Cellular & molecular mechanisms of drug resistance in cancer cells mutated for FBXW7 tumour suppressor gene
by: Lorenzi, Federica
Published: (2017)

Evaluating a rapid method to quantify multiple gene expression in acute myeloid leukaemia
by: Lee, Cin Dee
Published: (2013)

Advancing the clinical implementation of Clostridial cancer therapies
by: Zygouropoulou, Maria
Published: (2019)

Evaluation of neutrophil extracellular trap production in pregnancy
by: Tarbox, Rebecca Clare
Published: (2017)

Analysis of Madm, a novel adaptor protein that associates with Myeloid Leukemia Factor 1
by: Lim, Raelene
Published: (2003)

Physiological roles of macrophages
by: Gordon, Siamon, et al.
Published: (2017)

Immunomodulatory action of new curcumin analogue [2,6-BIS(2,5-dimethoxybenzylidene) cyclohexanone] on major inflammatory mediator expression in activated macrophage and synovial fibroblast cells
by: Lee, Ka Heng
Published: (2012)

Immune-instructive polymers for modulating macrophage phenotype
by: Alromaihi, Reem
Published: (2024)

Combining extracellular matrix hydrogels and electrical stimulation to influence macrophage polarisation
by: Whitehead, Charlie D.
Published: (2024)

Zebrafish embryonic and adult neutropoiesis display differential requirements for Gfi1 paralogs
by: Alsaiari, Jawaher
Published: (2025)

Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers
by: Lim, Hui Xuan *, et al.
Published: (2020)

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy
by: Crittenden, Marka R., et al.
Published: (2016)

Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells
by: Alharbi, Raed A., et al.
Published: (2017)

A study of microparticle shape and surface chemistry effects on interactions with macrophages
by: Bruce, Gordon
Published: (2021)

Identification of differentially expressed proteins as biomarkers of acute myeloid leukaemia
by: Barantalab, Fatemeh
Published: (2014)

Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment
by: Chulpanoval, Daria S., et al.
Published: (2018)

Targeting dormancy in acute myeloid leukaemia
by: Doolan, Lara
Published: (2023)

The impact of surface chemistry modification on macrophage polarisation
by: Rostam, Hassan, et al.
Published: (2016)

The effect of cigarette smoke extract on macrophages
by: Sharaf, Abeer
Published: (2018)

Macrophage phenotype in response to ECM bioscaffolds
by: Huleihel, Luai, et al.
Published: (2017)

The use of agonistic anti-CD40 therapy in treatments for cancer
by: Khong, A., et al.
Published: (2012)

Restoring mucosal barrier function and modifying macrophage phenotype with an extracellular matrix hydrogel: potential therapy for ulcerative colitis
by: Keane, Timothy J., et al.
Published: (2017)

The effect of Thymosine-ß4 on macrophage phenotype in Alzheimer’s disease
by: Hussain, Ikra
Published: (2019)

Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages
by: Günther, Juliane, et al.
Published: (2016)

In vitro treatment of MCF-7 and MDA-MB-231 breast cancer cell lines with doxorubicin and vincristine sulphate calcium carbonate nanoparticles
by: Mengyi, Xue
Published: (2019)

Incorporation of resident macrophages in engineered tissues: multiple cell type response to microenvironment controlled macrophage-laden gelatin hydrogels
by: Dollinger, Camille, et al.
Published: (2018)

Aged neutrophils accumulate in lymphoid tissues from healthy elderly mice and infiltrate T- and B-cell zones
by: Tomay, F., et al.
Published: (2018)

Construction of recombinant newcastle disease virus expressing granulocyte-macrophage colony-stimulating factor
by: Fikri Ooi, Nur Zafirah
Published: (2022)

Role of macrophage and associated cytokines in the regulation of breast tumour lymphovascular invasion
by: Ahmad, N.S.
Published: (2016)

Sarcostemma viminale activates macrophages to a pro-inflammatory phenotype
by: Brestovac, Brian, et al.
Published: (2014)

Targeting gp100 and TRP-2 with a DNA vaccine: incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial
by: Patel, Poulam M., et al.
Published: (2018)