Myocardial infarction after intravitreal vascular endothelial growth factor inhibitors: a whole population study
Purpose: To determine the risk of thromboembolic and gastrointestinal bleeding events in the 12 months after injections of bevacizumab or ranibizumab compared with photodynamic therapy and a non-treated community sample.Methods: Hospital and death records were examined for 1,267 patients treated wit...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
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Lippincott, Wliiams & Wilkins
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/21879 |
| _version_ | 1848750713595756544 |
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| author | Kemp, A. Preen, D. Morlet, Nigel Clark, Antony McAllister, I. Briffa, T. Sanfilippo, F. Ng, Jonathon McKnight, C. Reynolds, W. Gilles, M. |
| author_facet | Kemp, A. Preen, D. Morlet, Nigel Clark, Antony McAllister, I. Briffa, T. Sanfilippo, F. Ng, Jonathon McKnight, C. Reynolds, W. Gilles, M. |
| author_sort | Kemp, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Purpose: To determine the risk of thromboembolic and gastrointestinal bleeding events in the 12 months after injections of bevacizumab or ranibizumab compared with photodynamic therapy and a non-treated community sample.Methods: Hospital and death records were examined for 1,267 patients treated with vascular endothelial growth factor inhibitor and 399 patients treated with photodynamic therapy attending Western Australian eye clinics from 2002 to 2008, and 1,763 community controls, aged =50 years. Hospital records from 1995 to 2009 were analyzed for history of myocardial infarction (MI), stroke, and gastrointestinal bleeding before treatment. Records were searched for evidence of these events in the 12 months after treatment.Results: The 12-month MI rate was higher for vascular endothelial growth factor inhibitor patients than photodynamic therapy patients and the community group (1.9/100 vs. 0.8 and 0.7, respectively). No differences were observed between patients treated with bevacizumab and ranibizumab. The adjusted MI rate was 2.3 times greater than the community group (95% confidence interval, 1.2–4.5) and photodynamic therapy rate (95% confidence interval, 0.7–7.7). The 12-month MI risk did not increase with the number of injections administered (hazard ratio, 0.9; 95% confidence interval, 0.5–1.5). Stroke and gastrointestinal bleeding did not differ between any exposure groups.Conclusion: Although all the adverse events examined were rare, patients treated with vascular endothelial growth factor inhibitors were significantly more likely to experience fatal or nonfatal MI than the community group. This increased risk may be related to the underlying age-related macular degeneration or vascular endothelial growth factor inhibitor use itself. |
| first_indexed | 2025-11-14T07:41:12Z |
| format | Journal Article |
| id | curtin-20.500.11937-21879 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:41:12Z |
| publishDate | 2013 |
| publisher | Lippincott, Wliiams & Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-218792017-09-13T15:58:25Z Myocardial infarction after intravitreal vascular endothelial growth factor inhibitors: a whole population study Kemp, A. Preen, D. Morlet, Nigel Clark, Antony McAllister, I. Briffa, T. Sanfilippo, F. Ng, Jonathon McKnight, C. Reynolds, W. Gilles, M. stroke ranibizumab thromboembolic and gastrointestinal bleeding events photodynamic therapy bevacizumab myocardial infarction (MI) gastrointestinal bleeding vascular endothelial growth factor inhibitor Purpose: To determine the risk of thromboembolic and gastrointestinal bleeding events in the 12 months after injections of bevacizumab or ranibizumab compared with photodynamic therapy and a non-treated community sample.Methods: Hospital and death records were examined for 1,267 patients treated with vascular endothelial growth factor inhibitor and 399 patients treated with photodynamic therapy attending Western Australian eye clinics from 2002 to 2008, and 1,763 community controls, aged =50 years. Hospital records from 1995 to 2009 were analyzed for history of myocardial infarction (MI), stroke, and gastrointestinal bleeding before treatment. Records were searched for evidence of these events in the 12 months after treatment.Results: The 12-month MI rate was higher for vascular endothelial growth factor inhibitor patients than photodynamic therapy patients and the community group (1.9/100 vs. 0.8 and 0.7, respectively). No differences were observed between patients treated with bevacizumab and ranibizumab. The adjusted MI rate was 2.3 times greater than the community group (95% confidence interval, 1.2–4.5) and photodynamic therapy rate (95% confidence interval, 0.7–7.7). The 12-month MI risk did not increase with the number of injections administered (hazard ratio, 0.9; 95% confidence interval, 0.5–1.5). Stroke and gastrointestinal bleeding did not differ between any exposure groups.Conclusion: Although all the adverse events examined were rare, patients treated with vascular endothelial growth factor inhibitors were significantly more likely to experience fatal or nonfatal MI than the community group. This increased risk may be related to the underlying age-related macular degeneration or vascular endothelial growth factor inhibitor use itself. 2013 Journal Article http://hdl.handle.net/20.500.11937/21879 10.1097/IAE.0b013e318276e07b Lippincott, Wliiams & Wilkins restricted |
| spellingShingle | stroke ranibizumab thromboembolic and gastrointestinal bleeding events photodynamic therapy bevacizumab myocardial infarction (MI) gastrointestinal bleeding vascular endothelial growth factor inhibitor Kemp, A. Preen, D. Morlet, Nigel Clark, Antony McAllister, I. Briffa, T. Sanfilippo, F. Ng, Jonathon McKnight, C. Reynolds, W. Gilles, M. Myocardial infarction after intravitreal vascular endothelial growth factor inhibitors: a whole population study |
| title | Myocardial infarction after intravitreal vascular endothelial growth factor inhibitors: a whole population study |
| title_full | Myocardial infarction after intravitreal vascular endothelial growth factor inhibitors: a whole population study |
| title_fullStr | Myocardial infarction after intravitreal vascular endothelial growth factor inhibitors: a whole population study |
| title_full_unstemmed | Myocardial infarction after intravitreal vascular endothelial growth factor inhibitors: a whole population study |
| title_short | Myocardial infarction after intravitreal vascular endothelial growth factor inhibitors: a whole population study |
| title_sort | myocardial infarction after intravitreal vascular endothelial growth factor inhibitors: a whole population study |
| topic | stroke ranibizumab thromboembolic and gastrointestinal bleeding events photodynamic therapy bevacizumab myocardial infarction (MI) gastrointestinal bleeding vascular endothelial growth factor inhibitor |
| url | http://hdl.handle.net/20.500.11937/21879 |