Gastrointestinal Dysmotility in Rett Syndrome
Objectives: Through evidence review and the consensus of an expert panel, we developed recommendations for the clinical management of gastroesophageal reflux disease, constipation, and abdominal bloating in Rett syndrome.Methods: Based on review of the literature and family concerns expressed on Ret...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
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Lippincott Williams & Wilkins
2013
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| Online Access: | https://journals.lww.com/jpgn/toc/2014/02000 http://hdl.handle.net/20.500.11937/21838 |
| _version_ | 1848750702365507584 |
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| author | Baikie, G. Ravikumara, M. Downs, J. Naseem, N. Wong, K. Percy, A. Lane, J. Weiss, B. Ellaway, C. Bathgate, Katherine Leonard, H. |
| author_facet | Baikie, G. Ravikumara, M. Downs, J. Naseem, N. Wong, K. Percy, A. Lane, J. Weiss, B. Ellaway, C. Bathgate, Katherine Leonard, H. |
| author_sort | Baikie, G. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Objectives: Through evidence review and the consensus of an expert panel, we developed recommendations for the clinical management of gastroesophageal reflux disease, constipation, and abdominal bloating in Rett syndrome.Methods: Based on review of the literature and family concerns expressed on RettNet, initial draft recommendations were created. Wherein the literature was lacking, 25 open-ended questions were included. Input from an international, multidisciplinary panel of clinicians was sought using a 2-stage modified Delphi process to reach consensus agreement. Items related to the clinical assessment and management of gas troesophageal reflux disease, constipation, and abdominal bloating.Results: Consensus was achieved on 78 of 85 statements. A comprehensive approach to the assessment of gastroesophageal reflux and reflux disease, constipation, and abdominal bloating was recommended, taking into account impairment of communication skills in Rett syndrome. A stepwise approach to the management was identified with initial use of conservative strategies, escalating to pharmacological measures and surgery, if necessary.Conclusions: Gastrointestinal dysmotility occurs commonly in Rett syndrome. These evidence- and consensus-based recommendations have the potential to improve care of dysmotility issues in a rare condition and stimulate research to improve the present limited evidence base. |
| first_indexed | 2025-11-14T07:41:02Z |
| format | Journal Article |
| id | curtin-20.500.11937-21838 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:41:02Z |
| publishDate | 2013 |
| publisher | Lippincott Williams & Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-218382020-07-01T00:07:35Z Gastrointestinal Dysmotility in Rett Syndrome Baikie, G. Ravikumara, M. Downs, J. Naseem, N. Wong, K. Percy, A. Lane, J. Weiss, B. Ellaway, C. Bathgate, Katherine Leonard, H. Objectives: Through evidence review and the consensus of an expert panel, we developed recommendations for the clinical management of gastroesophageal reflux disease, constipation, and abdominal bloating in Rett syndrome.Methods: Based on review of the literature and family concerns expressed on RettNet, initial draft recommendations were created. Wherein the literature was lacking, 25 open-ended questions were included. Input from an international, multidisciplinary panel of clinicians was sought using a 2-stage modified Delphi process to reach consensus agreement. Items related to the clinical assessment and management of gas troesophageal reflux disease, constipation, and abdominal bloating.Results: Consensus was achieved on 78 of 85 statements. A comprehensive approach to the assessment of gastroesophageal reflux and reflux disease, constipation, and abdominal bloating was recommended, taking into account impairment of communication skills in Rett syndrome. A stepwise approach to the management was identified with initial use of conservative strategies, escalating to pharmacological measures and surgery, if necessary.Conclusions: Gastrointestinal dysmotility occurs commonly in Rett syndrome. These evidence- and consensus-based recommendations have the potential to improve care of dysmotility issues in a rare condition and stimulate research to improve the present limited evidence base. 2013 Journal Article http://hdl.handle.net/20.500.11937/21838 https://journals.lww.com/jpgn/toc/2014/02000 Lippincott Williams & Wilkins restricted |
| spellingShingle | Baikie, G. Ravikumara, M. Downs, J. Naseem, N. Wong, K. Percy, A. Lane, J. Weiss, B. Ellaway, C. Bathgate, Katherine Leonard, H. Gastrointestinal Dysmotility in Rett Syndrome |
| title | Gastrointestinal Dysmotility in Rett Syndrome |
| title_full | Gastrointestinal Dysmotility in Rett Syndrome |
| title_fullStr | Gastrointestinal Dysmotility in Rett Syndrome |
| title_full_unstemmed | Gastrointestinal Dysmotility in Rett Syndrome |
| title_short | Gastrointestinal Dysmotility in Rett Syndrome |
| title_sort | gastrointestinal dysmotility in rett syndrome |
| url | https://journals.lww.com/jpgn/toc/2014/02000 http://hdl.handle.net/20.500.11937/21838 |