Primary acute dengue and the deletion in chemokine receptor 5 (CCR5D32)
Dengue virus is a significant arboviral pathogen that is continuing to spread due to human travel and invasion of the mosquito vectors into new regions. Chemokine receptor 5 (CCR5) has a truncated 32 base pair deletion form (CCR5Δ32), which has been associated with resistance to HIV but increased se...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/21764 |
| _version_ | 1848750681253478400 |
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| author | Brestovac, Brian Harris, R. Halicki, Larissa Sampson, I. Speers, D. Mamotte, Cyril Williams, David |
| author_facet | Brestovac, Brian Harris, R. Halicki, Larissa Sampson, I. Speers, D. Mamotte, Cyril Williams, David |
| author_sort | Brestovac, Brian |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Dengue virus is a significant arboviral pathogen that is continuing to spread due to human travel and invasion of the mosquito vectors into new regions. Chemokine receptor 5 (CCR5) has a truncated 32 base pair deletion form (CCR5Δ32), which has been associated with resistance to HIV but increased severity in some flaviviral diseases. If CCR5Δ32 is associated with dengue, European carriers of this mutation may be at increased risk. In a Western Australian population with the same frequency of CCR5Δ32 (0.08) as that found in southern Europe there was no significant difference in CCR5Δ32 allele frequency between returned travellers with and without dengue (p = 0.82, OR = 0.86, 95% CI = 0.35–2.1). |
| first_indexed | 2025-11-14T07:40:42Z |
| format | Journal Article |
| id | curtin-20.500.11937-21764 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:40:42Z |
| publishDate | 2014 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-217642017-09-13T13:55:43Z Primary acute dengue and the deletion in chemokine receptor 5 (CCR5D32) Brestovac, Brian Harris, R. Halicki, Larissa Sampson, I. Speers, D. Mamotte, Cyril Williams, David Cysteine-cysteine chemokine receptor 5-32 base deletion (CCR5Δ32) Cysteine-cysteine chemokine receptor 5 (CCR5) Dengue virus (DENV) Flavivirus Vector Dengue virus is a significant arboviral pathogen that is continuing to spread due to human travel and invasion of the mosquito vectors into new regions. Chemokine receptor 5 (CCR5) has a truncated 32 base pair deletion form (CCR5Δ32), which has been associated with resistance to HIV but increased severity in some flaviviral diseases. If CCR5Δ32 is associated with dengue, European carriers of this mutation may be at increased risk. In a Western Australian population with the same frequency of CCR5Δ32 (0.08) as that found in southern Europe there was no significant difference in CCR5Δ32 allele frequency between returned travellers with and without dengue (p = 0.82, OR = 0.86, 95% CI = 0.35–2.1). 2014 Journal Article http://hdl.handle.net/20.500.11937/21764 10.1016/j.micinf.2014.02.007 Elsevier restricted |
| spellingShingle | Cysteine-cysteine chemokine receptor 5-32 base deletion (CCR5Δ32) Cysteine-cysteine chemokine receptor 5 (CCR5) Dengue virus (DENV) Flavivirus Vector Brestovac, Brian Harris, R. Halicki, Larissa Sampson, I. Speers, D. Mamotte, Cyril Williams, David Primary acute dengue and the deletion in chemokine receptor 5 (CCR5D32) |
| title | Primary acute dengue and the deletion in chemokine receptor 5 (CCR5D32) |
| title_full | Primary acute dengue and the deletion in chemokine receptor 5 (CCR5D32) |
| title_fullStr | Primary acute dengue and the deletion in chemokine receptor 5 (CCR5D32) |
| title_full_unstemmed | Primary acute dengue and the deletion in chemokine receptor 5 (CCR5D32) |
| title_short | Primary acute dengue and the deletion in chemokine receptor 5 (CCR5D32) |
| title_sort | primary acute dengue and the deletion in chemokine receptor 5 (ccr5d32) |
| topic | Cysteine-cysteine chemokine receptor 5-32 base deletion (CCR5Δ32) Cysteine-cysteine chemokine receptor 5 (CCR5) Dengue virus (DENV) Flavivirus Vector |
| url | http://hdl.handle.net/20.500.11937/21764 |