Validation and characterisation of a novel peptide that binds monomeric and aggregated beta-amyloid and inhibits the formation of neurotoxic oligomers

Validation and characterisation of a novel peptide that binds monomeric and aggregated beta-amyloid and inhibits the formation of neurotoxic oligomers

Although the formation of β-amyloid (Aβ) deposits in the brain is a hallmark of Alzheimer disease (AD), the soluble oligomers rather than the mature amyloid fibrils most likely contribute to Aβ toxicity and neurodegeneration. Thus, the discovery of agents targeting soluble Aβ oligomers is highly des...

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Bibliographic Details
Main Authors: Barr, R., Verdile, Giuseppe, Wijaya, L., Morici, M., Taddei, K., Gupta, V., Pedrini, S., Jin, L., Nicollazzo, J., Knock, E., Fraser, P., Martins, R.
Format: Journal Article
Published: 2015
Online Access:http://hdl.handle.net/20.500.11937/21753

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