Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations
Enhanced antifungal activity against the yeast species Candida albicans, Candida tropicalis and Saccharomyces cerevisiae was displayed by ZnS-ZnO nanocomposites prepared by a simple precipitation technique. The antifungal activity was significantly more in the presence of indoor light than under dar...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Royal Society of Chemistry
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/21585 |
| _version_ | 1848750630514982912 |
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| author | Suyana, P. Nishanth Kumar, S. Madhavan, N. Dileep Kumar, B. Nair, Balagopal Mohamed, A. Warrier, K. Hareesh, U. |
| author_facet | Suyana, P. Nishanth Kumar, S. Madhavan, N. Dileep Kumar, B. Nair, Balagopal Mohamed, A. Warrier, K. Hareesh, U. |
| author_sort | Suyana, P. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Enhanced antifungal activity against the yeast species Candida albicans, Candida tropicalis and Saccharomyces cerevisiae was displayed by ZnS-ZnO nanocomposites prepared by a simple precipitation technique. The antifungal activity was significantly more in the presence of indoor light than under dark conditions and was a clear confirmation of the inhibitory role of reactive oxygen species (ROS) generated in situ by the photocatalytic nanocomposites. The generation of ROS was further evidenced by flow cytometry results and membrane permeabilisation studies. Time kill assay and growth curve analysis indicated diminished antifungal activity under dark conditions due primarily to Zn2+ efflux in solution. © 2015 The Royal Society of Chemistry. |
| first_indexed | 2025-11-14T07:39:53Z |
| format | Journal Article |
| id | curtin-20.500.11937-21585 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:39:53Z |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-215852017-09-13T15:38:03Z Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations Suyana, P. Nishanth Kumar, S. Madhavan, N. Dileep Kumar, B. Nair, Balagopal Mohamed, A. Warrier, K. Hareesh, U. Enhanced antifungal activity against the yeast species Candida albicans, Candida tropicalis and Saccharomyces cerevisiae was displayed by ZnS-ZnO nanocomposites prepared by a simple precipitation technique. The antifungal activity was significantly more in the presence of indoor light than under dark conditions and was a clear confirmation of the inhibitory role of reactive oxygen species (ROS) generated in situ by the photocatalytic nanocomposites. The generation of ROS was further evidenced by flow cytometry results and membrane permeabilisation studies. Time kill assay and growth curve analysis indicated diminished antifungal activity under dark conditions due primarily to Zn2+ efflux in solution. © 2015 The Royal Society of Chemistry. 2015 Journal Article http://hdl.handle.net/20.500.11937/21585 10.1039/c5ra13316e Royal Society of Chemistry fulltext |
| spellingShingle | Suyana, P. Nishanth Kumar, S. Madhavan, N. Dileep Kumar, B. Nair, Balagopal Mohamed, A. Warrier, K. Hareesh, U. Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations |
| title | Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations |
| title_full | Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations |
| title_fullStr | Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations |
| title_full_unstemmed | Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations |
| title_short | Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations |
| title_sort | reactive oxygen species (ros) mediated enhanced anti-candidal activity of zns-zno nanocomposites with low inhibitory concentrations |
| url | http://hdl.handle.net/20.500.11937/21585 |