Amino acid bioconjugation via iClick reaction of an oxanorbornadiene-masked alkyne with a MnI(bpy)(CO)3-coordinated azide

Amino acid bioconjugation via iClick reaction of an oxanorbornadiene-masked alkyne with a MnI(bpy)(CO)3-coordinated azide

The catalyst-free room temperature iClick reaction of an unsymmetrically 2,3-disubstituted oxanorbornadiene (OND) as a “masked” alkyne equivalent with [Mn(N3)(bpyCH3,CH3)(CO)3] leads to isolation of a phenylalanine ester bioconjugate, in which the model amino acid is linked to the metal moiety via a...

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Bibliographic Details
Main Authors: Henry, L., Schneider, C., Mützel, B., Simpson, Peter, Nagel, C., Fucke, K., Schatzschneider, U.
Format: Journal Article
Published: 2014
Online Access:http://hdl.handle.net/20.500.11937/21454

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