Blood naltrexone levels over time following naltrexone implant
Aims: Oral naltrexone is used in the management of both heroin and alcohol dependence. However, poor compliance has limited its clinical utility. The study's objective was to determine the period of therapeutic coverage (= 2 ng/ml) provided by a 3.3 g naltrexone subcutaneous implant compared wi...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Published: |
2008
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| Online Access: | http://hdl.handle.net/20.500.11937/21334 |
| _version_ | 1848750561167409152 |
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| author | Ngo, H. Arnold-Reed, D. Hansson, R. Tait, Robert Hulse, G. |
| author_facet | Ngo, H. Arnold-Reed, D. Hansson, R. Tait, Robert Hulse, G. |
| author_sort | Ngo, H. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Aims: Oral naltrexone is used in the management of both heroin and alcohol dependence. However, poor compliance has limited its clinical utility. The study's objective was to determine the period of therapeutic coverage (= 2 ng/ml) provided by a 3.3 g naltrexone subcutaneous implant compared with existing data on 1.1 g and 2.2 g implants. Methods: We assessed free blood naltrexone levels following treatment with a 3.3 g naltrexone implant in heroin dependent patients (n = 50) in Perth, Western Australia. Results were compared with previously collated data for patients treated with either a 1.1 g (n = 10) or 2.2 g (n = 24) implant. Results: Following 3.3 g naltrexone implant treatment, free blood naltrexone levels remained above 2 ng/ml for 145 days (95% CI 125-167). In comparison, 1.1 g or 2.2 g implant treatment resulted in 95 days (95% CI 69-121) and 136 days (95% CI 114-158) coverage, respectively. Conclusions: The 3.3 g implant provides longer therapeutic coverage than the 1.1 g implant but not significantly longer than the 2.2 g implant. © 2007 Elsevier Inc. All rights reserved. |
| first_indexed | 2025-11-14T07:38:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-21334 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:38:47Z |
| publishDate | 2008 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-213342018-03-29T09:06:34Z Blood naltrexone levels over time following naltrexone implant Ngo, H. Arnold-Reed, D. Hansson, R. Tait, Robert Hulse, G. Aims: Oral naltrexone is used in the management of both heroin and alcohol dependence. However, poor compliance has limited its clinical utility. The study's objective was to determine the period of therapeutic coverage (= 2 ng/ml) provided by a 3.3 g naltrexone subcutaneous implant compared with existing data on 1.1 g and 2.2 g implants. Methods: We assessed free blood naltrexone levels following treatment with a 3.3 g naltrexone implant in heroin dependent patients (n = 50) in Perth, Western Australia. Results were compared with previously collated data for patients treated with either a 1.1 g (n = 10) or 2.2 g (n = 24) implant. Results: Following 3.3 g naltrexone implant treatment, free blood naltrexone levels remained above 2 ng/ml for 145 days (95% CI 125-167). In comparison, 1.1 g or 2.2 g implant treatment resulted in 95 days (95% CI 69-121) and 136 days (95% CI 114-158) coverage, respectively. Conclusions: The 3.3 g implant provides longer therapeutic coverage than the 1.1 g implant but not significantly longer than the 2.2 g implant. © 2007 Elsevier Inc. All rights reserved. 2008 Journal Article http://hdl.handle.net/20.500.11937/21334 10.1016/j.pnpbp.2007.06.007 restricted |
| spellingShingle | Ngo, H. Arnold-Reed, D. Hansson, R. Tait, Robert Hulse, G. Blood naltrexone levels over time following naltrexone implant |
| title | Blood naltrexone levels over time following naltrexone implant |
| title_full | Blood naltrexone levels over time following naltrexone implant |
| title_fullStr | Blood naltrexone levels over time following naltrexone implant |
| title_full_unstemmed | Blood naltrexone levels over time following naltrexone implant |
| title_short | Blood naltrexone levels over time following naltrexone implant |
| title_sort | blood naltrexone levels over time following naltrexone implant |
| url | http://hdl.handle.net/20.500.11937/21334 |