The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis
Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ. It consists of interconnecting steps all of which must be successfully completed to r...
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| Format: | Journal Article |
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Hindawi Publishing Corporation
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/21079 |
| _version_ | 1848750490419986432 |
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| author | Wong, C. Dye, Danielle Coombe, Deirdre |
| author_facet | Wong, C. Dye, Danielle Coombe, Deirdre |
| author_sort | Wong, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ. It consists of interconnecting steps all of which must be successfully completed to result in a metastasis. Cell-cell adhesion is a key aspect of many of these steps. Adhesion molecules belonging to the immunoglobulin superfamily (Ig-SF) commonly play a central role in cell-cell adhesion, and a number of these molecules have been associated with cancer progression and a metastatic phenotype. Surprisingly, the contribution of Ig-SF members to metastasis has not received the attention afforded other cell adhesion molecules (CAMs) such as the integrins. Here we examine the steps in the metastatic pathway focusing on how the Ig-SF members, melanoma cell adhesion molecule (MCAM), L1CAM, neural CAM (NCAM), leukocyte CAM (ALCAM), intercellular CAM-1 (ICAM-1) and platelet endothelial CAM-1 (PECAM-1) could play a role. Although much remains to be understood, this review aims to raise the profile of Ig-SF members in metastasis formation and prompt further research that could lead to useful clinical outcomes. |
| first_indexed | 2025-11-14T07:37:40Z |
| format | Journal Article |
| id | curtin-20.500.11937-21079 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:37:40Z |
| publishDate | 2012 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-210792017-09-13T15:59:13Z The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis Wong, C. Dye, Danielle Coombe, Deirdre metastatic lesion metastasis cancer Metastasis is a major clinical problem and results in a poor prognosis for most cancers. The metastatic pathway describes the process by which cancer cells give rise to a metastatic lesion in a new tissue or organ. It consists of interconnecting steps all of which must be successfully completed to result in a metastasis. Cell-cell adhesion is a key aspect of many of these steps. Adhesion molecules belonging to the immunoglobulin superfamily (Ig-SF) commonly play a central role in cell-cell adhesion, and a number of these molecules have been associated with cancer progression and a metastatic phenotype. Surprisingly, the contribution of Ig-SF members to metastasis has not received the attention afforded other cell adhesion molecules (CAMs) such as the integrins. Here we examine the steps in the metastatic pathway focusing on how the Ig-SF members, melanoma cell adhesion molecule (MCAM), L1CAM, neural CAM (NCAM), leukocyte CAM (ALCAM), intercellular CAM-1 (ICAM-1) and platelet endothelial CAM-1 (PECAM-1) could play a role. Although much remains to be understood, this review aims to raise the profile of Ig-SF members in metastasis formation and prompt further research that could lead to useful clinical outcomes. 2012 Journal Article http://hdl.handle.net/20.500.11937/21079 10.1155/2012/340296 Hindawi Publishing Corporation fulltext |
| spellingShingle | metastatic lesion metastasis cancer Wong, C. Dye, Danielle Coombe, Deirdre The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis |
| title | The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis |
| title_full | The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis |
| title_fullStr | The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis |
| title_full_unstemmed | The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis |
| title_short | The Role of Immunoglobulin Superfamily Cell Adhesion Molecules in Cancer Metastasis |
| title_sort | role of immunoglobulin superfamily cell adhesion molecules in cancer metastasis |
| topic | metastatic lesion metastasis cancer |
| url | http://hdl.handle.net/20.500.11937/21079 |