The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort
Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (I...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal Article |
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Elsevier BV
2013
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/20998 |
| _version_ | 1848750466603679744 |
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| author | Qiu, W. Pham, K. James, Ian Nolan, D. Castley, A. Christiansen, F. Czarniak, Petra Luo, Y. Wu, J. Garlepp, Michael Wilton, S. Carroll, W. Mastaglia, F. Kermode, A. |
| author_facet | Qiu, W. Pham, K. James, Ian Nolan, D. Castley, A. Christiansen, F. Czarniak, Petra Luo, Y. Wu, J. Garlepp, Michael Wilton, S. Carroll, W. Mastaglia, F. Kermode, A. |
| author_sort | Qiu, W. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/CD58, CLEC-16A/CTLA-4, and TYK2/IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups. |
| first_indexed | 2025-11-14T07:37:17Z |
| format | Journal Article |
| id | curtin-20.500.11937-20998 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:37:17Z |
| publishDate | 2013 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-209982017-09-13T13:46:48Z The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort Qiu, W. Pham, K. James, Ian Nolan, D. Castley, A. Christiansen, F. Czarniak, Petra Luo, Y. Wu, J. Garlepp, Michael Wilton, S. Carroll, W. Mastaglia, F. Kermode, A. Single nucleotide polymorphisms Non-HLA genes Multiple sclerosis HLA Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort of 350 MS patients and 498 population control subjects. Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. We also found evidence of interactive protective effects between polymorphisms in the IL7R/CD58, CLEC-16A/CTLA-4, and TYK2/IRF5 genes, which in some instances are restricted within HLA- or gender-defined groups. 2013 Journal Article http://hdl.handle.net/20.500.11937/20998 10.1016/j.jneuroim.2013.04.022 Elsevier BV restricted |
| spellingShingle | Single nucleotide polymorphisms Non-HLA genes Multiple sclerosis HLA Qiu, W. Pham, K. James, Ian Nolan, D. Castley, A. Christiansen, F. Czarniak, Petra Luo, Y. Wu, J. Garlepp, Michael Wilton, S. Carroll, W. Mastaglia, F. Kermode, A. The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort |
| title | The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort |
| title_full | The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort |
| title_fullStr | The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort |
| title_full_unstemmed | The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort |
| title_short | The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort |
| title_sort | influence of non-hla gene polymorphisms and interactions on disease risk in a western australian multiple sclerosis cohort |
| topic | Single nucleotide polymorphisms Non-HLA genes Multiple sclerosis HLA |
| url | http://hdl.handle.net/20.500.11937/20998 |