One step preparation and electrochemical analysis of IQS, a cell–cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa
Pseudomonas aeruginosa uses a hierarchical cell–cell communication system consisting of a number of regulatory elements to coordinate the expression of bacterial virulence genes. Sensitive detection of quorum sensing (QS) molecules has the potential for early identification of P. aeruginosa facilita...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Published: |
Pergamon
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/20987 |
| _version_ | 1848750463391891456 |
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| author | Shang, F. Muimhneacháin, E. Reen, F. Buzid, A. O'Gara, Fergal Luong, J. Glennon, J. McGlacken, G. |
| author_facet | Shang, F. Muimhneacháin, E. Reen, F. Buzid, A. O'Gara, Fergal Luong, J. Glennon, J. McGlacken, G. |
| author_sort | Shang, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pseudomonas aeruginosa uses a hierarchical cell–cell communication system consisting of a number of regulatory elements to coordinate the expression of bacterial virulence genes. Sensitive detection of quorum sensing (QS) molecules has the potential for early identification of P. aeruginosa facilitating early medical intervention. A recently isolated cell–cell communication molecule, a thiazole termed IQS, can bypass the las QS system of P. aeruginosa under times of stress, activating a subset of QS-controlled genes. This compound offers a new target for pathogen detection and has been prepared in a one step protocol. A simple electrochemical strategy was employed for its sensitive detection using boron-doped diamond and glassy carbon electrodes by cyclic voltammetry and amperometry. |
| first_indexed | 2025-11-14T07:37:14Z |
| format | Journal Article |
| id | curtin-20.500.11937-20987 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:37:14Z |
| publishDate | 2014 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-209872017-09-13T13:43:51Z One step preparation and electrochemical analysis of IQS, a cell–cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa Shang, F. Muimhneacháin, E. Reen, F. Buzid, A. O'Gara, Fergal Luong, J. Glennon, J. McGlacken, G. Pseudomonas aeruginosa uses a hierarchical cell–cell communication system consisting of a number of regulatory elements to coordinate the expression of bacterial virulence genes. Sensitive detection of quorum sensing (QS) molecules has the potential for early identification of P. aeruginosa facilitating early medical intervention. A recently isolated cell–cell communication molecule, a thiazole termed IQS, can bypass the las QS system of P. aeruginosa under times of stress, activating a subset of QS-controlled genes. This compound offers a new target for pathogen detection and has been prepared in a one step protocol. A simple electrochemical strategy was employed for its sensitive detection using boron-doped diamond and glassy carbon electrodes by cyclic voltammetry and amperometry. 2014 Journal Article http://hdl.handle.net/20.500.11937/20987 10.1016/j.bmcl.2014.08.023 Pergamon restricted |
| spellingShingle | Shang, F. Muimhneacháin, E. Reen, F. Buzid, A. O'Gara, Fergal Luong, J. Glennon, J. McGlacken, G. One step preparation and electrochemical analysis of IQS, a cell–cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa |
| title | One step preparation and electrochemical analysis of IQS, a cell–cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa |
| title_full | One step preparation and electrochemical analysis of IQS, a cell–cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa |
| title_fullStr | One step preparation and electrochemical analysis of IQS, a cell–cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa |
| title_full_unstemmed | One step preparation and electrochemical analysis of IQS, a cell–cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa |
| title_short | One step preparation and electrochemical analysis of IQS, a cell–cell communication signal in the nosocomial pathogen Pseudomonas aeruginosa |
| title_sort | one step preparation and electrochemical analysis of iqs, a cell–cell communication signal in the nosocomial pathogen pseudomonas aeruginosa |
| url | http://hdl.handle.net/20.500.11937/20987 |