Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides
We describe here the design, synthesis and evaluation of in vivo local anaesthetic and antiarrhythmic activities of a series of N-alkylproline anilides. Most of the compounds demonstrated surface anaesthetic activity higher than that of lidocaine, ropivacaine and bupivacaine. We established that the...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Elsevier Masson
2013
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| Online Access: | http://www.elsevier.com/locate/ejmech http://hdl.handle.net/20.500.11937/20875 |
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