The medicinal chemistry of novel iron Chelators for the treatment of cancer

QR Code

The medicinal chemistry of novel iron Chelators for the treatment of cancer

Cancer is one of the leading causes of death worldwide and there is an increasing need for novel anti-tumor therapeutics with greater selectivity and potency. A new strategy in the treatment of cancer has focused on targeting an essential cell metabolite, iron (Fe). Iron is vital for cell growth and...

Full description

Bibliographic Details
Main Authors:	Kovacevic, Z., Kalinowski, D., Lovejoy, D., Yu, Yu, Rahmanto, Y., Sharpe, P., Bernhardt, P., Richardson, D.
Format:	Journal Article
Published:	2011
Online Access:	http://hdl.handle.net/20.500.11937/20777

Similar Items

Iron chelators for the treatment of cancer
by: Yu, Yu, et al.
Published: (2012)

Bp44mT: An orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy
by: Yu, Yu, et al.
Published: (2012)

Thiosemicarbazone Iron Chelator: Evaluation of the anti-cancer activity and mechanisms of action
by: Yu, W., et al.
Published: (2011)

The potent and novel thiosemicarbazone chelators Di-2-pyridylketone-4,4- dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3- thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity
by: Yu, Yu, et al.
Published: (2011)

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2a, IRE1a, ATF6 and calmodulin kinase
by: Merlot, A., et al.
Published: (2016)

Bridging and chelation in organoantimony(V) chemistry
by: Gibbons, Martin Neil
Published: (1996)

Effect of iron chelators on proliferation and iron uptake in hepatoma cells
by: Kicic, Anthony, et al.
Published: (2001)

Iron chelates: a challenge to chemists and Mössbauer spectroscopists
by: Homonnay, Z., et al.
Published: (2008)

Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1
by: Yu, Yu, et al.
Published: (2011)

The desferrithiocin (DFT) class of iron chelators: Potential as antineoplastic agents
by: Kicic, Anthony, et al.
Published: (2001)

Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer
by: Coombs, G., et al.
Published: (2012)

The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health
by: Horniblow, Richard D., et al.
Published: (2016)

Role of epigallocatechin-3-gallate from green tea in iron chelation and endoplasmic reticulum stress pathway in colorectal cancer cells
by: Md Nesran, Zarith Nameyra
Published: (2018)

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics
by: Kalinowski, D., et al.
Published: (2016)

Determination of specific iron chelator by using LC-ICP-MS and LC-ESI-MS
by: Mohamed, Khairul Nizam, et al.
Published: (2015)

Precision medicine and future of cancer treatment
by: Lahiri, Chandrajit *, et al.
Published: (2019)

Iron in the biology and treatment of gastrointestinal cancer
by: Ng, Oliver C.T.
Published: (2019)

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase
by: Merlot, Angelica M., et al.
Published: (2016)

Generation, fractionation, and characterization of iron-chelating protein hydrolysate from palm kernel cake proteins
by: Zarei, Mohammad, et al.
Published: (2016)

Iron chelation properties of green tea Epigallocatechin-3-Gallate (EGCG) in colorectal cancer cells: analysis on Tfr/Fth regulations and molecular docking
by: Md Nesran, Zarith Nameyrra, et al.
Published: (2020)

Exploring Novel Silyl-Phosphonite Chemistry and New Bioisosteres
by: Wheeler, D F
Published: (2020)

Mechanisms underlying acquired platinum resistance in high grade serous ovarian cancer - a mini review
by: Binju, M., et al.
Published: (2019)

Novel nitrogen chemistry
by: Wheildon, Andrew R.
Published: (1999)

Synthesis of 3-dimensional scaffolds for application in medicinal chemistry
by: Schwehm, Carolin Maria
Published: (2016)

Iron Formations: Their Origins and Implications for Ancient Seawater Chemistry
by: Bekker, A., et al.
Published: (2014)

Metal chelating activity of Centella asiatica
by: Mohd Salim, Roshan Jahn, et al.
Published: (2010)

Novel orlistat LDL-like nanoparticles as potential anti-cancer medicines
by: Bebawy, George
Published: (2022)

Novel aspects of benzyne chemistry
by: Birkett, Michael Alexander
Published: (1994)

Benzyl and methyl fatty hydroxamic acids based on palm kernel oil as chelating agent for liquid-liquid iron(III) extraction.
by: Haron, Md Jelas, et al.
Published: (2012)

Benzyl and methyl fatty hydroxamic acids based on palm kernel oil as chelating agent for liquid-liquid iron (III) extraction.
by: Haron, Md. Jelas, et al.
Published: (2012)

Heat loss modelling and copper chelating from natural gas pipeline corossion
by: Hunt, D, et al.
Published: (2011)

An analysis of chloride…π(chelate ring) interactions
by: Tiekink, Edward R. T. *
Published: (2019)

Novel Water-Gas-Shift Reaction Catalyst from Iron-Loaded Victorian Brown Coal
by: Yu, J., et al.
Published: (2007)

The use and perceived benefits resulting from the use of complementary and alternative medicine by cancer patients in Australia
by: Oh, B., et al.
Published: (2010)

Potential Impacts and Modelling of the Heat Loss Due to Copper Chelation in Natural Gas Processing and Transport
by: Hunt, D., et al.
Published: (2011)

Isatin endowed metal chelates as antibacterial and antifungal agents
by: Khalid, Seher, et al.
Published: (2020)

Synthesis of Iron Oxide (Fe3O4) magnetic nanocrystals by green chemistry approach
by: W.S., Chiu, et al.
Published: (2014)

TYPLEX® Chelate, a novel feed additive, inhibits Campylobacter jejuni biofilm formation and cecal colonization in broiler chickens
by: Khattak, Farina, et al.
Published: (2018)

Botany, chemistry, and pharmaceutical significance of Sida cordifolia: a traditional medicinal plant
by: Ahmed, Hassan, et al.
Published: (2018)

Cancer survivors’ self-efficacy to self-manage in the year following primary treatment
by: Foster, Claire, et al.
Published: (2014)