Associations of objectively assessed Physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: Findings from NHANES (2003-2006)
Physical activity reduces the risk of postmenopausal breast cancer through multiple inter-related biologic mechanisms; sedentary time may contribute additionally to this risk. We examined cross-sectional associations of objectively assessed physical activity and sedentary time with established bioma...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/20596 |
| _version_ | 1848750350610202624 |
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| author | Lynch, B. Friedenreich, C. Winkler, E. Healy, Genevieve Vallance, J. Eakin, E. Owen, N. |
| author_facet | Lynch, B. Friedenreich, C. Winkler, E. Healy, Genevieve Vallance, J. Eakin, E. Owen, N. |
| author_sort | Lynch, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Physical activity reduces the risk of postmenopausal breast cancer through multiple inter-related biologic mechanisms; sedentary time may contribute additionally to this risk. We examined cross-sectional associations of objectively assessed physical activity and sedentary time with established biomarkers of breast cancer risk in a population-based sample of postmenopausal women. Accelerometer, anthropometric and laboratory data were available for 1,024 (n = 443 fasting) postmenopausal women in the U.S. National Health and Nutrition Examination Survey 2003-2006. Associations of quartiles of the accelerometer variables (moderate-to vigorousintensity activity, light-intensity activity and sedentary time per day; average length of active and sedentary bouts) with the continuous biomarkers were assessed using linear regression models. Following adjustment for potential confounders, including sedentary time, moderate-to vigorous-intensity activity had significant (P < 0.05), inverse associations with all biomarker outcomes (body mass index, waist circumference, C-reactive protein, fasting plasma glucose, fasting insulin and homeostasis model assessment of insulin resistance). Light-intensity activity and sedentary time were significantly associated in fully adjusted models with all biomarkers except fasting glucose. Active bout length was associated with a smaller waist circumference and lower C-reactive protein levels, while sedentary bout length was associated with a higher BMI. The associations of objectively assessed moderate-to vigorous-intensity activity with breast cancer biomarkers are consistent with the established beneficial effects of selfreported exercise on breast cancer risk. Our findings further suggest that light-intensity activity may have a protective effect, and that sedentary time may independently contribute to breast cancer risk. |
| first_indexed | 2025-11-14T07:35:26Z |
| format | Journal Article |
| id | curtin-20.500.11937-20596 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:35:26Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-205962017-09-13T13:48:57Z Associations of objectively assessed Physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: Findings from NHANES (2003-2006) Lynch, B. Friedenreich, C. Winkler, E. Healy, Genevieve Vallance, J. Eakin, E. Owen, N. Physical activity reduces the risk of postmenopausal breast cancer through multiple inter-related biologic mechanisms; sedentary time may contribute additionally to this risk. We examined cross-sectional associations of objectively assessed physical activity and sedentary time with established biomarkers of breast cancer risk in a population-based sample of postmenopausal women. Accelerometer, anthropometric and laboratory data were available for 1,024 (n = 443 fasting) postmenopausal women in the U.S. National Health and Nutrition Examination Survey 2003-2006. Associations of quartiles of the accelerometer variables (moderate-to vigorousintensity activity, light-intensity activity and sedentary time per day; average length of active and sedentary bouts) with the continuous biomarkers were assessed using linear regression models. Following adjustment for potential confounders, including sedentary time, moderate-to vigorous-intensity activity had significant (P < 0.05), inverse associations with all biomarker outcomes (body mass index, waist circumference, C-reactive protein, fasting plasma glucose, fasting insulin and homeostasis model assessment of insulin resistance). Light-intensity activity and sedentary time were significantly associated in fully adjusted models with all biomarkers except fasting glucose. Active bout length was associated with a smaller waist circumference and lower C-reactive protein levels, while sedentary bout length was associated with a higher BMI. The associations of objectively assessed moderate-to vigorous-intensity activity with breast cancer biomarkers are consistent with the established beneficial effects of selfreported exercise on breast cancer risk. Our findings further suggest that light-intensity activity may have a protective effect, and that sedentary time may independently contribute to breast cancer risk. 2011 Journal Article http://hdl.handle.net/20.500.11937/20596 10.1007/s10549-011-1559-2 restricted |
| spellingShingle | Lynch, B. Friedenreich, C. Winkler, E. Healy, Genevieve Vallance, J. Eakin, E. Owen, N. Associations of objectively assessed Physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: Findings from NHANES (2003-2006) |
| title | Associations of objectively assessed Physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: Findings from NHANES (2003-2006) |
| title_full | Associations of objectively assessed Physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: Findings from NHANES (2003-2006) |
| title_fullStr | Associations of objectively assessed Physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: Findings from NHANES (2003-2006) |
| title_full_unstemmed | Associations of objectively assessed Physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: Findings from NHANES (2003-2006) |
| title_short | Associations of objectively assessed Physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: Findings from NHANES (2003-2006) |
| title_sort | associations of objectively assessed physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: findings from nhanes (2003-2006) |
| url | http://hdl.handle.net/20.500.11937/20596 |