Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil-based chemotherapy

Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil-based chemotherapy

Background & Aims: Patients with colorectal tumors with microsatellite instability (MSI) have better prognoses than patients with tumors without MSI, but have a poor response to 5-fluorouracil–based chemotherapy. A dominant-negative form of heat shock protein (HSP)110 (HSP110DE9) expressed by ca...

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Main Authors: Collura, A., Lagrange, A., Svrcek, M., Marisa, L., Buhard, O., Guilloux, A., Wanherdrick, K., Dorard, C., Taieb, A., Saget, A., Loh, M., Soong, R., Zeps, Nikolajs, Platell, C., Mews, A., Iacopetta, B., De Thonel, A., Seigneuric, R., Marcion, G., Chapusot, C., Lepage, C., Bouvier, A., Gaub, M., Milano, G., Selves, J., Senet, P., Delarue, P., Arzouk, H., Lacoste, C., Coquelle, A., Bengrine-Lefèvre, L., Tournigand, C., Lefèvre, J., Parc, Y., Biard, D., Fléjou, J., Garrido, C., Duval, A.
Format: Journal Article
Published: 2014
Online Access:http://hdl.handle.net/20.500.11937/20530

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