Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. PPRs were prepared by addition of -cyclodextrin rings to functionalized polyethylene glycol (PEG) chain...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Elsevier BV
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/20427 |
| _version_ | 1848750302206885888 |
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| author | Hosseini, F. Panahifar, A. Adeli, M. Amiri, H. Lascialfari, A. Orsini, F. Doschak, Michael Mahmoudi, M. |
| author_facet | Hosseini, F. Panahifar, A. Adeli, M. Amiri, H. Lascialfari, A. Orsini, F. Doschak, Michael Mahmoudi, M. |
| author_sort | Hosseini, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. PPRs were prepared by addition of -cyclodextrin rings to functionalized polyethylene glycol (PEG) chain with hydrophobic triazine end-groups. Non-covalent interactions between SPIONs and PPRs led to the assembly of SPIONs@PRs hybrid nanomaterials. Measurements of the 1H Nuclear Magnetic Resonance (NMR) relaxation times T1 and T2 allowed us to determine the NMR dispersion profiles. Comparison between our SPIONs@PRs hybrid nano-compound and the commercial SPION compound, Endorem®, showed a higher transverse relaxivity for SPIONs@PRs. In vitro MRI experiments showed that our SPIONs@PRs produces better negative contrast compared to Endorem® and can be considered as a novel MRI contrast agent. |
| first_indexed | 2025-11-14T07:34:40Z |
| format | Journal Article |
| id | curtin-20.500.11937-20427 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:34:40Z |
| publishDate | 2013 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-204272017-09-13T13:48:14Z Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent Hosseini, F. Panahifar, A. Adeli, M. Amiri, H. Lascialfari, A. Orsini, F. Doschak, Michael Mahmoudi, M. Nanomedicine MRI contrast agent Supermolecules SPIONs Hybrid nanomaterials Polyrotaxanes Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized and coated with pseudopolyrotaxanes (PPRs) and proposed as a novel hybrid nanostructure for medical imaging and drug delivery. PPRs were prepared by addition of -cyclodextrin rings to functionalized polyethylene glycol (PEG) chain with hydrophobic triazine end-groups. Non-covalent interactions between SPIONs and PPRs led to the assembly of SPIONs@PRs hybrid nanomaterials. Measurements of the 1H Nuclear Magnetic Resonance (NMR) relaxation times T1 and T2 allowed us to determine the NMR dispersion profiles. Comparison between our SPIONs@PRs hybrid nano-compound and the commercial SPION compound, Endorem®, showed a higher transverse relaxivity for SPIONs@PRs. In vitro MRI experiments showed that our SPIONs@PRs produces better negative contrast compared to Endorem® and can be considered as a novel MRI contrast agent. 2013 Journal Article http://hdl.handle.net/20.500.11937/20427 10.1016/j.colsurfb.2012.10.035 Elsevier BV restricted |
| spellingShingle | Nanomedicine MRI contrast agent Supermolecules SPIONs Hybrid nanomaterials Polyrotaxanes Hosseini, F. Panahifar, A. Adeli, M. Amiri, H. Lascialfari, A. Orsini, F. Doschak, Michael Mahmoudi, M. Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent |
| title | Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent |
| title_full | Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent |
| title_fullStr | Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent |
| title_full_unstemmed | Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent |
| title_short | Synthesis of pseudopolyrotaxanes-coated Superparamagnetic Iron Oxide Nanoparticles as new MRI contrast agent |
| title_sort | synthesis of pseudopolyrotaxanes-coated superparamagnetic iron oxide nanoparticles as new mri contrast agent |
| topic | Nanomedicine MRI contrast agent Supermolecules SPIONs Hybrid nanomaterials Polyrotaxanes |
| url | http://hdl.handle.net/20.500.11937/20427 |