Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases
The Vanin genes are a family that encode pantetheinases involved in recycling Coenzyme A, catalysing the breakdown of intermediate pantetheine to vitamin B5 for reuse in CoA biosynthesis. The role of pantetheinase in this most fundamental of cellular processes, was substantially characterised by the...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2012
|
| Online Access: | http://hdl.handle.net/20.500.11937/20391 |
| _version_ | 1848750292516995072 |
|---|---|
| author | Kaskow, B. Michael Proffit, J. Blangero, J. Moses, Eric Abraham, L. |
| author_facet | Kaskow, B. Michael Proffit, J. Blangero, J. Moses, Eric Abraham, L. |
| author_sort | Kaskow, B. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The Vanin genes are a family that encode pantetheinases involved in recycling Coenzyme A, catalysing the breakdown of intermediate pantetheine to vitamin B5 for reuse in CoA biosynthesis. The role of pantetheinase in this most fundamental of cellular processes, was substantially characterised by the 1970s. The next 20 years saw little further interest in pantetheinase until various genetic studies implicated the Vanin locus in a range of normal and disease phenotypes, and a consequent interest in the other product of pantetheinase activity, cysteamine. This report seeks to bring together the early biochemical studies with recent biological data implicating cysteamine as a regulator of the oxidative state of a cell. Numerous studies now report a role for Vanin in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease. |
| first_indexed | 2025-11-14T07:34:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-20391 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:34:31Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-203912018-03-29T09:06:33Z Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases Kaskow, B. Michael Proffit, J. Blangero, J. Moses, Eric Abraham, L. The Vanin genes are a family that encode pantetheinases involved in recycling Coenzyme A, catalysing the breakdown of intermediate pantetheine to vitamin B5 for reuse in CoA biosynthesis. The role of pantetheinase in this most fundamental of cellular processes, was substantially characterised by the 1970s. The next 20 years saw little further interest in pantetheinase until various genetic studies implicated the Vanin locus in a range of normal and disease phenotypes, and a consequent interest in the other product of pantetheinase activity, cysteamine. This report seeks to bring together the early biochemical studies with recent biological data implicating cysteamine as a regulator of the oxidative state of a cell. Numerous studies now report a role for Vanin in inflammation, oxidative stress, cell migration and numerous diseases including cardiovascular disease. 2012 Journal Article http://hdl.handle.net/20.500.11937/20391 10.1016/j.bbrc.2011.11.099 restricted |
| spellingShingle | Kaskow, B. Michael Proffit, J. Blangero, J. Moses, Eric Abraham, L. Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases |
| title | Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases |
| title_full | Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases |
| title_fullStr | Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases |
| title_full_unstemmed | Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases |
| title_short | Diverse biological activities of the vascular non-inflammatory molecules - The Vanin pantetheinases |
| title_sort | diverse biological activities of the vascular non-inflammatory molecules - the vanin pantetheinases |
| url | http://hdl.handle.net/20.500.11937/20391 |