Key role of phosphoinositide 3-kinase class IB in pancreatic cancer
Purpose: Phosphoinositide 3-kinase (PI3K) signaling is well established as important in cancer. To date most studies have been focused on the PI3K/p110a isoform, which has been found to be mutated in several different cancers. The aim of our study was to determine which specific PI3K isoforms are in...
| Main Authors: | Edling, C., Selvaggi, F., Buus, R., Maffucci, T., Di Sebastiano, P., Friess, H., Innocenti, P., Kocher, H., Falasca, Marco |
|---|---|
| Format: | Journal Article |
| Published: |
American Association Cancer Research
2010
|
| Online Access: | http://hdl.handle.net/20.500.11937/20327 |
Similar Items
Targeting phosphoinositide 3-kinase pathways in pancreatic cancer - from molecular signalling to clinical trials
by: Falasca, Marco, et al.
Published: (2011)
by: Falasca, Marco, et al.
Published: (2011)
Regulation and cellular functions of class II phosphoinositide 3-kinases
by: Falasca, Marco, et al.
Published: (2012)
by: Falasca, Marco, et al.
Published: (2012)
New insight into the intracellular roles of class II phosphoinositide 3-kinases
by: Maffucci, T., et al.
Published: (2014)
by: Maffucci, T., et al.
Published: (2014)
Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway
by: Edling, C., et al.
Published: (2014)
by: Edling, C., et al.
Published: (2014)
Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic ß cells
by: Dominguez, V., et al.
Published: (2011)
by: Dominguez, V., et al.
Published: (2011)
Investigating the mechanisms of activation and action of phosphoinositide 3-kinase C2 alpha in pancreatic beta cells
by: Mazza, S., et al.
Published: (2013)
by: Mazza, S., et al.
Published: (2013)
Genetic and epigenetic regulation of phosphoinositide 3-kinase isoforms
by: Fyffe, C., et al.
Published: (2013)
by: Fyffe, C., et al.
Published: (2013)
Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis
by: Tibolla, G., et al.
Published: (2013)
by: Tibolla, G., et al.
Published: (2013)
Class II Phosphoinositide 3-Kinases as Novel Drug Targets
by: Falasca, Marco, et al.
Published: (2017)
by: Falasca, Marco, et al.
Published: (2017)
Novel roles for class II Phosphoinositide 3-Kinase C2ß in signalling pathways involved in prostate cancer cell invasion.
by: Mavrommati, I., et al.
Published: (2016)
by: Mavrommati, I., et al.
Published: (2016)
Analysis, regulation, and roles of endosomal phosphoinositides
by: Maffucci, T., et al.
Published: (2014)
by: Maffucci, T., et al.
Published: (2014)
Phosphoinositide 3-kinase pathway inhibitors: pharmacology, metabolism & drug development
by: Falasca, Marco
Published: (2011)
by: Falasca, Marco
Published: (2011)
Class II phosphoinositide 3-kinase C2ß regulates a novel signaling pathway involved in breast cancer progression.
by: Chikh, A., et al.
Published: (2016)
by: Chikh, A., et al.
Published: (2016)
3-phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer
by: Fyffe, C., et al.
Published: (2013)
by: Fyffe, C., et al.
Published: (2013)
THE CLASS II PHOSPHOINOSITIDE 3-KINASE ISOFORM beta REGULATES PLATELET FUNCTION AND ARTERIAL THROMBOSIS IN MICE
by: Tibolla, G., et al.
Published: (2011)
by: Tibolla, G., et al.
Published: (2011)
A phosphoinositide 3-kinase/phospholipase cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation
by: Maffucci, T., et al.
Published: (2009)
by: Maffucci, T., et al.
Published: (2009)
Functional association of phosphoinositide-3-kinase with platelet glycoprotein Iba, the major ligand-binding subunit of the glycoprotein Ib-IX-V complex
by: Mu, F., et al.
Published: (2010)
by: Mu, F., et al.
Published: (2010)
Phosphoinositides signalling in cancer: Focus on PI3K and PLC
by: Raimondi, C., et al.
Published: (2012)
by: Raimondi, C., et al.
Published: (2012)
Elucidation of the WNT & AKT/Phosphoinositide-3-Kinase Pathways in Colorectal Carcinoma
by: Khor, Tin Oo
Published: (2004)
by: Khor, Tin Oo
Published: (2004)
PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma
by: Dituri, F., et al.
Published: (2012)
by: Dituri, F., et al.
Published: (2012)
Diet and pancreatic cancer prevention
by: Casari, I., et al.
Published: (2015)
by: Casari, I., et al.
Published: (2015)
Emerging role of the KRAS-PDK1 axis in pancreatic cancer
by: Ferro, R., et al.
Published: (2014)
by: Ferro, R., et al.
Published: (2014)
Pancreatic ductal adenocarcinoma: Current and evolving therapies
by: Adamska, A., et al.
Published: (2017)
by: Adamska, A., et al.
Published: (2017)
Pancreatic cancer: Current research and future directions
by: Falasca, Marco, et al.
Published: (2016)
by: Falasca, Marco, et al.
Published: (2016)
Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts
by: Falasca, Marco, et al.
Published: (2014)
by: Falasca, Marco, et al.
Published: (2014)
Rethinking phosphatidylinositol 3-monophosphate
by: Falasca, Marco, et al.
Published: (2009)
by: Falasca, Marco, et al.
Published: (2009)
ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward?
by: Adamska, A., et al.
Published: (2018)
by: Adamska, A., et al.
Published: (2018)
Akt/protein kinase B in skeletal muscle physiology and pathology
by: Wu, M., et al.
Published: (2011)
by: Wu, M., et al.
Published: (2011)
GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine
by: Ferro, R., et al.
Published: (2018)
by: Ferro, R., et al.
Published: (2018)
Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer
by: Elaskalani, O., et al.
Published: (2017)
by: Elaskalani, O., et al.
Published: (2017)
PITPs as targets for selectively interfering with phosphoinositide signaling in cells
by: Nile, A., et al.
Published: (2014)
by: Nile, A., et al.
Published: (2014)
Cudraflavone C induces tumor-specific apoptosis in colorectal cancer cells through inhibition of the phosphoinositide 3-kinase (PI3K)-AKT pathway
by: Castresana, Javier S., et al.
Published: (2017)
by: Castresana, Javier S., et al.
Published: (2017)
Molecular and cellular mechanisms of chemoresistance in pancreatic cancer
by: Adamska, Aleksandra, et al.
Published: (2018)
by: Adamska, Aleksandra, et al.
Published: (2018)
Genetic markers in a Malaysian population: variants of uridine monophosphate kinase (UMPK), phosphoglycolate phosphatase (PGP) and pancreatic amylase (AMY₂)
by: K. H., Zarinah, et al.
Published: (1984)
by: K. H., Zarinah, et al.
Published: (1984)
GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine
by: Ferro, Riccardo, et al.
Published: (2018)
by: Ferro, Riccardo, et al.
Published: (2018)
The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation
by: Pieiro, R., et al.
Published: (2011)
by: Pieiro, R., et al.
Published: (2011)
Boyden chamber
by: Falasca, Marco, et al.
Published: (2011)
by: Falasca, Marco, et al.
Published: (2011)
Cancer chemoprevention with nuts.
by: Falasca, Marco, et al.
Published: (2014)
by: Falasca, Marco, et al.
Published: (2014)
PI3K CLASS 1B CONTROLS THE CELL CYCLE CHECKPOINT AT THE G2/M PHASE PROMOTING CELL PROLIFERATION IN HEPATOCELLULAR CARCINOMA
by: Dituri, F., et al.
Published: (2011)
by: Dituri, F., et al.
Published: (2011)
The role of platelet-derived ADP and ATP in promoting pancreatic cancer cell survival and gemcitabine resistance
by: Elaskalani, Omar, et al.
Published: (2017)
by: Elaskalani, Omar, et al.
Published: (2017)
Similar Items
-
Targeting phosphoinositide 3-kinase pathways in pancreatic cancer - from molecular signalling to clinical trials
by: Falasca, Marco, et al.
Published: (2011) -
Regulation and cellular functions of class II phosphoinositide 3-kinases
by: Falasca, Marco, et al.
Published: (2012) -
New insight into the intracellular roles of class II phosphoinositide 3-kinases
by: Maffucci, T., et al.
Published: (2014) -
Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway
by: Edling, C., et al.
Published: (2014) -
Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic ß cells
by: Dominguez, V., et al.
Published: (2011)