Inhalable Curcumin Formulations: Micronization and Bioassay
Inhalable formulations of curcumin with hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone have been produced by a newly developed anti-solvent micronization technique based on the supercritical fluid (SCF) technology. The micronization process used is the atomized rapid injection solvent extract...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
Elsevier BV
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/20058 |
| _version_ | 1848750203764473856 |
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| author | Kurniawansyan, F. Duong, H. Danh, L. Mammucari, R. Vittorio, O. Boyer, C. Foster, Neil |
| author_facet | Kurniawansyan, F. Duong, H. Danh, L. Mammucari, R. Vittorio, O. Boyer, C. Foster, Neil |
| author_sort | Kurniawansyan, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Inhalable formulations of curcumin with hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone have been produced by a newly developed anti-solvent micronization technique based on the supercritical fluid (SCF) technology. The micronization process used is the atomized rapid injection solvent extraction process (ARISE), which utilizes high pressure carbon dioxide as the anti-solvent. The composition, particle morphology and aerodynamic performance of the samples were observed. Curcumin formulations with aerodynamic performance suitable for inhalation delivery have been produced and tested in vitro using normal and lung cancer cells (MRC-5 cells and H1299 cells, respectively). The cytotoxicity study revealed that the encapsulation of curcumin improved its biodistribution and solubility for lung cancer cells. A rapid cell uptake was observed for all formulations by confocal microscopy and flow cytometry. Fluorescence life time imaging microscopy showed a rapid release of curcumin in the cells. Results show that co-processing by ARISE preserved the anticancer properties of curcumin and generated inhalable powders thus demonstrating potential in the localized treatment of lung cancer. |
| first_indexed | 2025-11-14T07:33:06Z |
| format | Journal Article |
| id | curtin-20.500.11937-20058 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:33:06Z |
| publishDate | 2015 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-200582017-09-13T13:48:13Z Inhalable Curcumin Formulations: Micronization and Bioassay Kurniawansyan, F. Duong, H. Danh, L. Mammucari, R. Vittorio, O. Boyer, C. Foster, Neil Inhalable formulations of curcumin with hydroxypropyl-β-cyclodextrin and polyvinylpyrrolidone have been produced by a newly developed anti-solvent micronization technique based on the supercritical fluid (SCF) technology. The micronization process used is the atomized rapid injection solvent extraction process (ARISE), which utilizes high pressure carbon dioxide as the anti-solvent. The composition, particle morphology and aerodynamic performance of the samples were observed. Curcumin formulations with aerodynamic performance suitable for inhalation delivery have been produced and tested in vitro using normal and lung cancer cells (MRC-5 cells and H1299 cells, respectively). The cytotoxicity study revealed that the encapsulation of curcumin improved its biodistribution and solubility for lung cancer cells. A rapid cell uptake was observed for all formulations by confocal microscopy and flow cytometry. Fluorescence life time imaging microscopy showed a rapid release of curcumin in the cells. Results show that co-processing by ARISE preserved the anticancer properties of curcumin and generated inhalable powders thus demonstrating potential in the localized treatment of lung cancer. 2015 Journal Article http://hdl.handle.net/20.500.11937/20058 10.1016/j.cej.2015.05.087 Elsevier BV restricted |
| spellingShingle | Kurniawansyan, F. Duong, H. Danh, L. Mammucari, R. Vittorio, O. Boyer, C. Foster, Neil Inhalable Curcumin Formulations: Micronization and Bioassay |
| title | Inhalable Curcumin Formulations: Micronization and Bioassay |
| title_full | Inhalable Curcumin Formulations: Micronization and Bioassay |
| title_fullStr | Inhalable Curcumin Formulations: Micronization and Bioassay |
| title_full_unstemmed | Inhalable Curcumin Formulations: Micronization and Bioassay |
| title_short | Inhalable Curcumin Formulations: Micronization and Bioassay |
| title_sort | inhalable curcumin formulations: micronization and bioassay |
| url | http://hdl.handle.net/20.500.11937/20058 |