Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS
2-Heptyl-3-hydroxy-4-quinolone (PQS) and its precursor 2-heptyl-4-quinolone (HHQ) are key signalling molecules of the important nosocomial pathogen Pseudomonas aeruginosa. We have recently reported an interkingdom dimension to these molecules, influencing key virulence traits in a broad spectrum of...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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Royal Society of Chemistry
2012
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| Online Access: | http://hdl.handle.net/20.500.11937/19919 |
| _version_ | 1848750165525004288 |
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| author | Reen, F. Clarke, S. Legendre, C. McSweeney, C. Eccles, K. Lawrence, S. O'Gara, Fergal McGlacken, G. |
| author_facet | Reen, F. Clarke, S. Legendre, C. McSweeney, C. Eccles, K. Lawrence, S. O'Gara, Fergal McGlacken, G. |
| author_sort | Reen, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | 2-Heptyl-3-hydroxy-4-quinolone (PQS) and its precursor 2-heptyl-4-quinolone (HHQ) are key signalling molecules of the important nosocomial pathogen Pseudomonas aeruginosa. We have recently reported an interkingdom dimension to these molecules, influencing key virulence traits in a broad spectrum of microbial species and in the human pathogenic yeast Candida albicans. For the first time, targeted chemical derivatisation of the C-3 position was undertaken to investigate the structural and molecular properties underpinning the biological activity of these compounds in P. aeruginosa, and using Bacillus subtilis as a suitable model system for investigating modulation of interspecies behaviour. |
| first_indexed | 2025-11-14T07:32:30Z |
| format | Journal Article |
| id | curtin-20.500.11937-19919 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:32:30Z |
| publishDate | 2012 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-199192017-09-13T13:51:03Z Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS Reen, F. Clarke, S. Legendre, C. McSweeney, C. Eccles, K. Lawrence, S. O'Gara, Fergal McGlacken, G. 2-Heptyl-3-hydroxy-4-quinolone (PQS) and its precursor 2-heptyl-4-quinolone (HHQ) are key signalling molecules of the important nosocomial pathogen Pseudomonas aeruginosa. We have recently reported an interkingdom dimension to these molecules, influencing key virulence traits in a broad spectrum of microbial species and in the human pathogenic yeast Candida albicans. For the first time, targeted chemical derivatisation of the C-3 position was undertaken to investigate the structural and molecular properties underpinning the biological activity of these compounds in P. aeruginosa, and using Bacillus subtilis as a suitable model system for investigating modulation of interspecies behaviour. 2012 Journal Article http://hdl.handle.net/20.500.11937/19919 10.1039/c2ob26823j Royal Society of Chemistry restricted |
| spellingShingle | Reen, F. Clarke, S. Legendre, C. McSweeney, C. Eccles, K. Lawrence, S. O'Gara, Fergal McGlacken, G. Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS |
| title | Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS |
| title_full | Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS |
| title_fullStr | Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS |
| title_full_unstemmed | Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS |
| title_short | Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS |
| title_sort | structure-function analysis of the c-3 position in analogues of microbial behavioural modulators hhq and pqs |
| url | http://hdl.handle.net/20.500.11937/19919 |