ASPREE-D: Aspirin for the prevention of depression in the elderly
Copyright © International Psychogeriatric Association 2016. Background:: Not only is depression associated with increased inflammation but inflammation is a risk factor for the genesis of depression. Many of the environmental risk factors for depression are transduced through inflammatory signaling....
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Cambridge University Press
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/19735 |
| _version_ | 1848750114911289344 |
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| author | Berk, M. Woods, R. Nelson, M. Shah, R. Reid, Christopher Storey, E. Fitzgerald, S. Lockery, J. Wolfe, R. Mohebbi, M. Murray, A. Kirpach, B. Grimm, R. McNeil, J. |
| author_facet | Berk, M. Woods, R. Nelson, M. Shah, R. Reid, Christopher Storey, E. Fitzgerald, S. Lockery, J. Wolfe, R. Mohebbi, M. Murray, A. Kirpach, B. Grimm, R. McNeil, J. |
| author_sort | Berk, M. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Copyright © International Psychogeriatric Association 2016. Background:: Not only is depression associated with increased inflammation but inflammation is a risk factor for the genesis of depression. Many of the environmental risk factors for depression are transduced through inflammatory signaling. Anti-inflammatory agents show promise for the management of depression in preclinical, epidemiological, and early clinical studies. This opens the door to the potential for anti-inflammatory agents to treat and prevent depression. There are no evidence-based pharmacotherapies for depression prevention. Method:: ASPREE-D, aspirin in the prevention of depression in the elderly, is a sub study of ASPREE, which explores the potential of aspirin to prevent a range of inflammation related disorders in the elderly. With a sample size of 19,114, and a duration of 5 years, this placebo controlled study will be one of the largest randomized controlled trials in psychiatry and will provide definitive evidence on the ability of aspirin to prevent depression. Results:: This paper presents the rationale for the study and presents a summary of the study design. Conclusions:: ASPREE-D may not only define novel therapy but will provide mechanistic proof of concept of the role of inflammation in depression. |
| first_indexed | 2025-11-14T07:31:41Z |
| format | Journal Article |
| id | curtin-20.500.11937-19735 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:31:41Z |
| publishDate | 2016 |
| publisher | Cambridge University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-197352017-09-13T13:51:03Z ASPREE-D: Aspirin for the prevention of depression in the elderly Berk, M. Woods, R. Nelson, M. Shah, R. Reid, Christopher Storey, E. Fitzgerald, S. Lockery, J. Wolfe, R. Mohebbi, M. Murray, A. Kirpach, B. Grimm, R. McNeil, J. Copyright © International Psychogeriatric Association 2016. Background:: Not only is depression associated with increased inflammation but inflammation is a risk factor for the genesis of depression. Many of the environmental risk factors for depression are transduced through inflammatory signaling. Anti-inflammatory agents show promise for the management of depression in preclinical, epidemiological, and early clinical studies. This opens the door to the potential for anti-inflammatory agents to treat and prevent depression. There are no evidence-based pharmacotherapies for depression prevention. Method:: ASPREE-D, aspirin in the prevention of depression in the elderly, is a sub study of ASPREE, which explores the potential of aspirin to prevent a range of inflammation related disorders in the elderly. With a sample size of 19,114, and a duration of 5 years, this placebo controlled study will be one of the largest randomized controlled trials in psychiatry and will provide definitive evidence on the ability of aspirin to prevent depression. Results:: This paper presents the rationale for the study and presents a summary of the study design. Conclusions:: ASPREE-D may not only define novel therapy but will provide mechanistic proof of concept of the role of inflammation in depression. 2016 Journal Article http://hdl.handle.net/20.500.11937/19735 10.1017/S104161021600079X Cambridge University Press fulltext |
| spellingShingle | Berk, M. Woods, R. Nelson, M. Shah, R. Reid, Christopher Storey, E. Fitzgerald, S. Lockery, J. Wolfe, R. Mohebbi, M. Murray, A. Kirpach, B. Grimm, R. McNeil, J. ASPREE-D: Aspirin for the prevention of depression in the elderly |
| title | ASPREE-D: Aspirin for the prevention of depression in the elderly |
| title_full | ASPREE-D: Aspirin for the prevention of depression in the elderly |
| title_fullStr | ASPREE-D: Aspirin for the prevention of depression in the elderly |
| title_full_unstemmed | ASPREE-D: Aspirin for the prevention of depression in the elderly |
| title_short | ASPREE-D: Aspirin for the prevention of depression in the elderly |
| title_sort | aspree-d: aspirin for the prevention of depression in the elderly |
| url | http://hdl.handle.net/20.500.11937/19735 |