PEDF-induced alteration of metabolism leading to insulin resistance
Pigment epithelium-derived factor (PEDF) is an anti-angiogenic, immunomodulatory, and neurotrophic serine protease inhibitor protein. PEDF is evolving as a novel metabolic regulatory protein that plays a causal role in insulin resistance. Insulin resistance is the central pathogenesis of metabolic d...
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| Format: | Journal Article |
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Elsevier Ireland Ltd
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/19606 |
| _version_ | 1848750079788187648 |
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| author | Carnagarin, Revathy Dharmarajan, Arunasalam Dass, Crispin |
| author_facet | Carnagarin, Revathy Dharmarajan, Arunasalam Dass, Crispin |
| author_sort | Carnagarin, Revathy |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Pigment epithelium-derived factor (PEDF) is an anti-angiogenic, immunomodulatory, and neurotrophic serine protease inhibitor protein. PEDF is evolving as a novel metabolic regulatory protein that plays a causal role in insulin resistance. Insulin resistance is the central pathogenesis of metabolic disorders such as obesity, type 2 diabetes mellitus, polycystic ovarian disease, and metabolic syndrome, and PEDF is associated with them. The current evidence suggests that PEDF administration to animals induces insulin resistance, whereas neutralisation improves insulin sensitivity. Inflammation, lipolytic free fatty acid mobilisation, and mitochondrial dysfunction are the proposed mechanism of PEDF-mediated insulin resistance. This review summarises the probable mechanisms adopted by PEDF to induce insulin resistance, and identifies PEDF as a potential therapeutic target in ameliorating insulin resistance. |
| first_indexed | 2025-11-14T07:31:08Z |
| format | Journal Article |
| id | curtin-20.500.11937-19606 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:31:08Z |
| publishDate | 2015 |
| publisher | Elsevier Ireland Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-196062017-09-13T13:44:33Z PEDF-induced alteration of metabolism leading to insulin resistance Carnagarin, Revathy Dharmarajan, Arunasalam Dass, Crispin Obesity PEDF Metabolism Insulin Diabetes Pigment epithelium-derived factor (PEDF) is an anti-angiogenic, immunomodulatory, and neurotrophic serine protease inhibitor protein. PEDF is evolving as a novel metabolic regulatory protein that plays a causal role in insulin resistance. Insulin resistance is the central pathogenesis of metabolic disorders such as obesity, type 2 diabetes mellitus, polycystic ovarian disease, and metabolic syndrome, and PEDF is associated with them. The current evidence suggests that PEDF administration to animals induces insulin resistance, whereas neutralisation improves insulin sensitivity. Inflammation, lipolytic free fatty acid mobilisation, and mitochondrial dysfunction are the proposed mechanism of PEDF-mediated insulin resistance. This review summarises the probable mechanisms adopted by PEDF to induce insulin resistance, and identifies PEDF as a potential therapeutic target in ameliorating insulin resistance. 2015 Journal Article http://hdl.handle.net/20.500.11937/19606 10.1016/j.mce.2014.11.006 Elsevier Ireland Ltd restricted |
| spellingShingle | Obesity PEDF Metabolism Insulin Diabetes Carnagarin, Revathy Dharmarajan, Arunasalam Dass, Crispin PEDF-induced alteration of metabolism leading to insulin resistance |
| title | PEDF-induced alteration of metabolism leading to insulin resistance |
| title_full | PEDF-induced alteration of metabolism leading to insulin resistance |
| title_fullStr | PEDF-induced alteration of metabolism leading to insulin resistance |
| title_full_unstemmed | PEDF-induced alteration of metabolism leading to insulin resistance |
| title_short | PEDF-induced alteration of metabolism leading to insulin resistance |
| title_sort | pedf-induced alteration of metabolism leading to insulin resistance |
| topic | Obesity PEDF Metabolism Insulin Diabetes |
| url | http://hdl.handle.net/20.500.11937/19606 |