The risk of Cerebral Palsy in survivors of multiple pregnancies with co-fetal loss or death

Objective. This study investigated the risks for cerebral palsy in survivors of multiple pregnancies with cofetal loss (< 20 weeks gestation) or cofetal death. Study Design. The total Western Australian population-based case-control study included 741 cases of cerebral palsy. Results. Antenatal c...

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Main Authors: Taylor, Catherine, de Groot, J., Blair, E., Stanley, F.
Format: Journal Article
Published: Mosby, Inc. 2009
Online Access:http://hdl.handle.net/20.500.11937/19542
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author Taylor, Catherine
de Groot, J.
Blair, E.
Stanley, F.
author_facet Taylor, Catherine
de Groot, J.
Blair, E.
Stanley, F.
author_sort Taylor, Catherine
building Curtin Institutional Repository
collection Online Access
description Objective. This study investigated the risks for cerebral palsy in survivors of multiple pregnancies with cofetal loss (< 20 weeks gestation) or cofetal death. Study Design. The total Western Australian population-based case-control study included 741 cases of cerebral palsy. Results. Antenatal cofetal loss or death occurred in 3% of all cases of cerebral palsy, which is a small but significant contribution. The odds ratio for cerebral palsy in survivors of cofetal loss that included iatrogenic pregnancy reduction was 2.65 (95% confidence interval [CI], 0.78-8.98), which gave a population-attributable proportion of 7.28% (95% CI, 0-27.5), compared with 4.25 (95% CI, 1.12-16.10) and 10.6% (95% CI, 1.0-35.6) for survivors of cofetal death. Conclusion. This study quantifies the contribution of cofetal death to cerebral palsy and suggests that cofetal loss makes a similar, although somewhat smaller, contribution to the risk for cerebral palsy in survivors of multiple pregnancies.
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spelling curtin-20.500.11937-195422017-09-13T21:30:38Z The risk of Cerebral Palsy in survivors of multiple pregnancies with co-fetal loss or death Taylor, Catherine de Groot, J. Blair, E. Stanley, F. Objective. This study investigated the risks for cerebral palsy in survivors of multiple pregnancies with cofetal loss (< 20 weeks gestation) or cofetal death. Study Design. The total Western Australian population-based case-control study included 741 cases of cerebral palsy. Results. Antenatal cofetal loss or death occurred in 3% of all cases of cerebral palsy, which is a small but significant contribution. The odds ratio for cerebral palsy in survivors of cofetal loss that included iatrogenic pregnancy reduction was 2.65 (95% confidence interval [CI], 0.78-8.98), which gave a population-attributable proportion of 7.28% (95% CI, 0-27.5), compared with 4.25 (95% CI, 1.12-16.10) and 10.6% (95% CI, 1.0-35.6) for survivors of cofetal death. Conclusion. This study quantifies the contribution of cofetal death to cerebral palsy and suggests that cofetal loss makes a similar, although somewhat smaller, contribution to the risk for cerebral palsy in survivors of multiple pregnancies. 2009 Journal Article http://hdl.handle.net/20.500.11937/19542 10.1016/j.ajog.2009.02.003 Mosby, Inc. fulltext
spellingShingle Taylor, Catherine
de Groot, J.
Blair, E.
Stanley, F.
The risk of Cerebral Palsy in survivors of multiple pregnancies with co-fetal loss or death
title The risk of Cerebral Palsy in survivors of multiple pregnancies with co-fetal loss or death
title_full The risk of Cerebral Palsy in survivors of multiple pregnancies with co-fetal loss or death
title_fullStr The risk of Cerebral Palsy in survivors of multiple pregnancies with co-fetal loss or death
title_full_unstemmed The risk of Cerebral Palsy in survivors of multiple pregnancies with co-fetal loss or death
title_short The risk of Cerebral Palsy in survivors of multiple pregnancies with co-fetal loss or death
title_sort risk of cerebral palsy in survivors of multiple pregnancies with co-fetal loss or death
url http://hdl.handle.net/20.500.11937/19542