The era of genome-wide association studies: Opportunities and challenges for asthma genetics
In the era of genome-wide association (GWA) studies, delineating pathogenic asthma genetic pathways has provided both challenges and opportunities. Initial GWA studies on asthma and asthma-like phenotypes provided some successes in terms of ascertaining new potential asthma candidate genes. However,...
| Main Authors: | , , |
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| Format: | Journal Article |
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Nature Publishing Group
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/19534 |
| _version_ | 1848750060434620416 |
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| author | Zhang, Guicheng Goldblatt, J. Lesouëf, P. |
| author_facet | Zhang, Guicheng Goldblatt, J. Lesouëf, P. |
| author_sort | Zhang, Guicheng |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | In the era of genome-wide association (GWA) studies, delineating pathogenic asthma genetic pathways has provided both challenges and opportunities. Initial GWA studies on asthma and asthma-like phenotypes provided some successes in terms of ascertaining new potential asthma candidate genes. However, due to asthma having a heterogeneous etiology, replications of these genotype-phenotype association studies are generally lacking. Furthermore, genes by environment interactions are generally not considered when GWA studies are conducted. Therefore, there is a need for extensive collaborations in multi-disciplinary research fields, including different environments and populations, to investigate the functional importance of variations in the human genome in relation to asthma pathogenesis. © 2009 The Japan Society of Human Genetics All rights reserved. |
| first_indexed | 2025-11-14T07:30:50Z |
| format | Journal Article |
| id | curtin-20.500.11937-19534 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:30:50Z |
| publishDate | 2009 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-195342017-09-13T13:44:33Z The era of genome-wide association studies: Opportunities and challenges for asthma genetics Zhang, Guicheng Goldblatt, J. Lesouëf, P. In the era of genome-wide association (GWA) studies, delineating pathogenic asthma genetic pathways has provided both challenges and opportunities. Initial GWA studies on asthma and asthma-like phenotypes provided some successes in terms of ascertaining new potential asthma candidate genes. However, due to asthma having a heterogeneous etiology, replications of these genotype-phenotype association studies are generally lacking. Furthermore, genes by environment interactions are generally not considered when GWA studies are conducted. Therefore, there is a need for extensive collaborations in multi-disciplinary research fields, including different environments and populations, to investigate the functional importance of variations in the human genome in relation to asthma pathogenesis. © 2009 The Japan Society of Human Genetics All rights reserved. 2009 Journal Article http://hdl.handle.net/20.500.11937/19534 10.1038/jhg.2009.97 Nature Publishing Group unknown |
| spellingShingle | Zhang, Guicheng Goldblatt, J. Lesouëf, P. The era of genome-wide association studies: Opportunities and challenges for asthma genetics |
| title | The era of genome-wide association studies: Opportunities and challenges for asthma genetics |
| title_full | The era of genome-wide association studies: Opportunities and challenges for asthma genetics |
| title_fullStr | The era of genome-wide association studies: Opportunities and challenges for asthma genetics |
| title_full_unstemmed | The era of genome-wide association studies: Opportunities and challenges for asthma genetics |
| title_short | The era of genome-wide association studies: Opportunities and challenges for asthma genetics |
| title_sort | era of genome-wide association studies: opportunities and challenges for asthma genetics |
| url | http://hdl.handle.net/20.500.11937/19534 |