CD31 signals confer immune privilege to the vascular endothelium
Maintenance of vascular integrity during effector immune responses occurring in tissues is a prerequisite of a healthy immune response. The mechanism whereby the vascular endothelium remains undamaged while interacting with effector immune cells migrating to the site of inflammation is largely unkno...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
2015
|
| Online Access: | http://hdl.handle.net/20.500.11937/19397 |
| _version_ | 1848750021885820928 |
|---|---|
| author | Cheung, K. Ma, L. Wang, G. Coe, D. Ferro, R. Falasca, Marco Buckley, C. Mauro, C. Marelli-Berg, F. |
| author_facet | Cheung, K. Ma, L. Wang, G. Coe, D. Ferro, R. Falasca, Marco Buckley, C. Mauro, C. Marelli-Berg, F. |
| author_sort | Cheung, K. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Maintenance of vascular integrity during effector immune responses occurring in tissues is a prerequisite of a healthy immune response. The mechanism whereby the vascular endothelium remains undamaged while interacting with effector immune cells migrating to the site of inflammation is largely unknown. This study shows that signals mediated by CD31, a trans-homophilic receptor expressed at high levels by the endothelium, are both necessary and sufficient to prevent inflammation-induced endothelial cell death and confer immune privilege to the vascular endothelium. We also provide proof of principle that this property can be harnessed therapeutically in pancreatic β-cell transplantation, whereby CD31 gene transfer alone endows allogeneic targets with indefinite resistance to immune attack in vivo. |
| first_indexed | 2025-11-14T07:30:13Z |
| format | Journal Article |
| id | curtin-20.500.11937-19397 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:30:13Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-193972017-09-13T13:46:47Z CD31 signals confer immune privilege to the vascular endothelium Cheung, K. Ma, L. Wang, G. Coe, D. Ferro, R. Falasca, Marco Buckley, C. Mauro, C. Marelli-Berg, F. Maintenance of vascular integrity during effector immune responses occurring in tissues is a prerequisite of a healthy immune response. The mechanism whereby the vascular endothelium remains undamaged while interacting with effector immune cells migrating to the site of inflammation is largely unknown. This study shows that signals mediated by CD31, a trans-homophilic receptor expressed at high levels by the endothelium, are both necessary and sufficient to prevent inflammation-induced endothelial cell death and confer immune privilege to the vascular endothelium. We also provide proof of principle that this property can be harnessed therapeutically in pancreatic β-cell transplantation, whereby CD31 gene transfer alone endows allogeneic targets with indefinite resistance to immune attack in vivo. 2015 Journal Article http://hdl.handle.net/20.500.11937/19397 10.1073/pnas.1509627112 unknown |
| spellingShingle | Cheung, K. Ma, L. Wang, G. Coe, D. Ferro, R. Falasca, Marco Buckley, C. Mauro, C. Marelli-Berg, F. CD31 signals confer immune privilege to the vascular endothelium |
| title | CD31 signals confer immune privilege to the vascular endothelium |
| title_full | CD31 signals confer immune privilege to the vascular endothelium |
| title_fullStr | CD31 signals confer immune privilege to the vascular endothelium |
| title_full_unstemmed | CD31 signals confer immune privilege to the vascular endothelium |
| title_short | CD31 signals confer immune privilege to the vascular endothelium |
| title_sort | cd31 signals confer immune privilege to the vascular endothelium |
| url | http://hdl.handle.net/20.500.11937/19397 |