Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic ß-cell line and mouse islets

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Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic ß-cell line and mouse islets

Interleukin-6 (IL6) has recently been reported to promote insulin secretion in a glucagon-like peptide-1-dependent manner. Herein, the direct effects of IL6 (at various concentrations from 0 to 1000 pg/ml) on pancreatic β-cell metabolism, AMP-activated protein kinase (AMPK) signaling, insulin secret...

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Bibliographic Details
Main Authors:	Da Silva Krause, M., Bittencourt, A., de Bittencourt, P., McClenaghan, N., Flatt, P., Murphy, C., Newsholme, Philip
Format:	Journal Article
Published:	BioScientifica Ltd. 2012
Online Access:	http://hdl.handle.net/20.500.11937/19062

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