Pulling out the 1%: Whole-Genome Capture for the Targeted Enrichment of Ancient DNA Sequencing Libraries

Pulling out the 1%: Whole-Genome Capture for the Targeted Enrichment of Ancient DNA Sequencing Libraries

Most ancient specimens contain very low levels of endogenous DNA, precluding the shotgun sequencing of many interesting samples because of cost. Ancient DNA (aDNA) libraries often contain <1% endogenous DNA, with the majority of sequencing capacity taken up by environmental DNA. Here we prese...

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Bibliographic Details
Main Authors: Carpenter, M., Buenrostro, J., Valdiosera, C., Schroeder, H., Allentoft, M., Sikora, M., Rasmussen, M., Gravel, S., Guillen, S., Nekhrizov, G., Leshtakov, K., Dimitrova, D., Theodossiev, N., Petterner, D., Luiselli, D., Sandoval, K., Moreno-Estrada, A., Li, Y., Wang, Jun, Gilbert, Thomas, Willerslev, E., Greenleaf, W., Bustamante, C.
Format: Journal Article
Published: University of Chicago Press 2013
Online Access:http://www.sciencedirect.com/science/article/pii/S000292971300459X
http://hdl.handle.net/20.500.11937/19047

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