Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults
Background: Albumin serves a range of physiological functions that are vital to overall brain and cognitive health. Indeed, associations between cognitive performance and albumin have been demonstrated in individuals with chronic liver or kidney disease and in patients with a high urinary excretion...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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S. Karger AG
2014
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| Online Access: | http://hdl.handle.net/20.500.11937/19039 |
| _version_ | 1848749919839453184 |
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| author | Lam, Virginie Albrecht, Matthew Takechi, Ryu Haidari-Nejad, S. Foster, Jonathan Mamo, John |
| author_facet | Lam, Virginie Albrecht, Matthew Takechi, Ryu Haidari-Nejad, S. Foster, Jonathan Mamo, John |
| author_sort | Lam, Virginie |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Albumin serves a range of physiological functions that are vital to overall brain and cognitive health. Indeed, associations between cognitive performance and albumin have been demonstrated in individuals with chronic liver or kidney disease and in patients with a high urinary excretion of albumin. However, an association of plasma albumin with cognitive performance has not been reported in otherwise healthy participants with clinically acceptable plasma albumin concentrations. Method: This study utilized a wide-ranging neuropsychological test battery to investigate the relationship between cognitive performance and plasma albumin homeostasis in 222 healthy participants (143 females) between the ages of 43 and 84 years (mean 65 years). Results: Albumin both with and without the covariates of age, sex and acute-phase proteins was positively associated with enhanced performance on a range of neuropsychological domains including perceptual speed, Stroop and verbal ability. Albumin manifested generally positive but less robust associations with secondary and primary memory. Conclusion: The results indicate that there is a positive association between albumin and cognitive performance in physiologically healthy participants free of chronic renal or liver disease. |
| first_indexed | 2025-11-14T07:28:35Z |
| format | Journal Article |
| id | curtin-20.500.11937-19039 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:28:35Z |
| publishDate | 2014 |
| publisher | S. Karger AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-190392019-02-19T04:26:27Z Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults Lam, Virginie Albrecht, Matthew Takechi, Ryu Haidari-Nejad, S. Foster, Jonathan Mamo, John Plasma albumin Bayesian analysis Neurovascular inflammation Neuropsychological performance Background: Albumin serves a range of physiological functions that are vital to overall brain and cognitive health. Indeed, associations between cognitive performance and albumin have been demonstrated in individuals with chronic liver or kidney disease and in patients with a high urinary excretion of albumin. However, an association of plasma albumin with cognitive performance has not been reported in otherwise healthy participants with clinically acceptable plasma albumin concentrations. Method: This study utilized a wide-ranging neuropsychological test battery to investigate the relationship between cognitive performance and plasma albumin homeostasis in 222 healthy participants (143 females) between the ages of 43 and 84 years (mean 65 years). Results: Albumin both with and without the covariates of age, sex and acute-phase proteins was positively associated with enhanced performance on a range of neuropsychological domains including perceptual speed, Stroop and verbal ability. Albumin manifested generally positive but less robust associations with secondary and primary memory. Conclusion: The results indicate that there is a positive association between albumin and cognitive performance in physiologically healthy participants free of chronic renal or liver disease. 2014 Journal Article http://hdl.handle.net/20.500.11937/19039 10.1159/000356967 S. Karger AG fulltext |
| spellingShingle | Plasma albumin Bayesian analysis Neurovascular inflammation Neuropsychological performance Lam, Virginie Albrecht, Matthew Takechi, Ryu Haidari-Nejad, S. Foster, Jonathan Mamo, John Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults |
| title | Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults |
| title_full | Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults |
| title_fullStr | Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults |
| title_full_unstemmed | Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults |
| title_short | Neuropsychological Performance is Positively Associated with Plasma Albumin in Healthy Adults |
| title_sort | neuropsychological performance is positively associated with plasma albumin in healthy adults |
| topic | Plasma albumin Bayesian analysis Neurovascular inflammation Neuropsychological performance |
| url | http://hdl.handle.net/20.500.11937/19039 |