Inhalable curcumin formulations by supercritical technology
Inhalable dry formulations for pulmonary delivery of curcumin have been produced by supercritical antisolvent micronization. The antioxidant curcumin was co-processed with hydroxypropyl-beta-cyclodextrin (HP-ß-CD) and polyvinylpyrrolidone (PVP) to form binary and ternary composites with enhanced flo...
| Main Authors: | , , |
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| Format: | Journal Article |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/20.500.11937/19028 |
| _version_ | 1848749916243886080 |
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| author | Kurniawansyah, F. Mammucari, R. Foster, Neil |
| author_facet | Kurniawansyah, F. Mammucari, R. Foster, Neil |
| author_sort | Kurniawansyah, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Inhalable dry formulations for pulmonary delivery of curcumin have been produced by supercritical antisolvent micronization. The antioxidant curcumin was co-processed with hydroxypropyl-beta-cyclodextrin (HP-ß-CD) and polyvinylpyrrolidone (PVP) to form binary and ternary composites with enhanced flow-ability for pulmonary delivery. The micronization process adopted was the atomized rapid injection solvent extraction (ARISE) system, and was operated at 95 bar and at temperatures of 25 °C and 40 °C. The products were evaluated in terms of morphology, composition, crystallinity and aerodynamic particle size distributions. A synergistic effect of the excipients on the aerodynamic properties of micronized curcumin formulations has been found. The fine particle fraction (FPF) of curcumin in ARISE-processed powders was as high as 61% in ternary systems, whilst untreated curcumin had a FPF of 10% and micronized binary systems had FPF below 40%. The process produced yields of about 80%, demonstrating significant potential for further development of curcumin formulations for pulmonary administration. |
| first_indexed | 2025-11-14T07:28:32Z |
| format | Journal Article |
| id | curtin-20.500.11937-19028 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:28:32Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-190282017-09-13T13:44:33Z Inhalable curcumin formulations by supercritical technology Kurniawansyah, F. Mammucari, R. Foster, Neil Inhalable dry formulations for pulmonary delivery of curcumin have been produced by supercritical antisolvent micronization. The antioxidant curcumin was co-processed with hydroxypropyl-beta-cyclodextrin (HP-ß-CD) and polyvinylpyrrolidone (PVP) to form binary and ternary composites with enhanced flow-ability for pulmonary delivery. The micronization process adopted was the atomized rapid injection solvent extraction (ARISE) system, and was operated at 95 bar and at temperatures of 25 °C and 40 °C. The products were evaluated in terms of morphology, composition, crystallinity and aerodynamic particle size distributions. A synergistic effect of the excipients on the aerodynamic properties of micronized curcumin formulations has been found. The fine particle fraction (FPF) of curcumin in ARISE-processed powders was as high as 61% in ternary systems, whilst untreated curcumin had a FPF of 10% and micronized binary systems had FPF below 40%. The process produced yields of about 80%, demonstrating significant potential for further development of curcumin formulations for pulmonary administration. 2015 Journal Article http://hdl.handle.net/20.500.11937/19028 10.1016/j.powtec.2015.04.083 Elsevier restricted |
| spellingShingle | Kurniawansyah, F. Mammucari, R. Foster, Neil Inhalable curcumin formulations by supercritical technology |
| title | Inhalable curcumin formulations by supercritical technology |
| title_full | Inhalable curcumin formulations by supercritical technology |
| title_fullStr | Inhalable curcumin formulations by supercritical technology |
| title_full_unstemmed | Inhalable curcumin formulations by supercritical technology |
| title_short | Inhalable curcumin formulations by supercritical technology |
| title_sort | inhalable curcumin formulations by supercritical technology |
| url | http://hdl.handle.net/20.500.11937/19028 |