The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep
Gastrointestinal nematode parasites in farmed animals are of particular importance due to their effects on production. In Australia, it is estimated that the direct and indirect effects of parasite infestation cost the animal production industries hundreds of millions of dollars each year. The main...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
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Hindawi Publishing Corporation
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/18903 |
| _version_ | 1848749880513658880 |
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| author | Lee, C. Munyard, Kylie Gregg, Keith Wetherall, John Stear, M. Groth, David |
| author_facet | Lee, C. Munyard, Kylie Gregg, Keith Wetherall, John Stear, M. Groth, David |
| author_sort | Lee, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Gastrointestinal nematode parasites in farmed animals are of particular importance due to their effects on production. In Australia, it is estimated that the direct and indirect effects of parasite infestation cost the animal production industries hundreds of millions of dollars each year. The main factors considered by immunologists when studying gastrointestinal nematode infections are the effects the host's response has on the parasite, which immunological components are responsible for these effects, genetic factors involved in controlling immunological responses, and the interactions between these forming an interconnecting multilevel relationship. In this paper, we describe the roles of immunoglobulins, in particular IgA and IgE, and the major histocompatibility complex in resistance to gastrointestinal parasites in sheep. We also draw evidence from other animal models to support the involvement of these immune components. Finally, we examine how IgA and IgE exert their influence and how methods may be developed to manage susceptible animals. |
| first_indexed | 2025-11-14T07:27:58Z |
| format | Journal Article |
| id | curtin-20.500.11937-18903 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:27:58Z |
| publishDate | 2011 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-189032017-09-13T16:04:40Z The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep Lee, C. Munyard, Kylie Gregg, Keith Wetherall, John Stear, M. Groth, David Gastrointestinal Parasites Immunoglobulin E Sheep immunoglobulin A MHC Gastrointestinal nematode parasites in farmed animals are of particular importance due to their effects on production. In Australia, it is estimated that the direct and indirect effects of parasite infestation cost the animal production industries hundreds of millions of dollars each year. The main factors considered by immunologists when studying gastrointestinal nematode infections are the effects the host's response has on the parasite, which immunological components are responsible for these effects, genetic factors involved in controlling immunological responses, and the interactions between these forming an interconnecting multilevel relationship. In this paper, we describe the roles of immunoglobulins, in particular IgA and IgE, and the major histocompatibility complex in resistance to gastrointestinal parasites in sheep. We also draw evidence from other animal models to support the involvement of these immune components. Finally, we examine how IgA and IgE exert their influence and how methods may be developed to manage susceptible animals. 2011 Journal Article http://hdl.handle.net/20.500.11937/18903 10.1155/2011/101848 Hindawi Publishing Corporation fulltext |
| spellingShingle | Gastrointestinal Parasites Immunoglobulin E Sheep immunoglobulin A MHC Lee, C. Munyard, Kylie Gregg, Keith Wetherall, John Stear, M. Groth, David The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep |
| title | The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep |
| title_full | The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep |
| title_fullStr | The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep |
| title_full_unstemmed | The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep |
| title_short | The Influence of MHC and Immunoglobulins A and E on Host Resistance to Gastrointestinal Nematodes in Sheep |
| title_sort | influence of mhc and immunoglobulins a and e on host resistance to gastrointestinal nematodes in sheep |
| topic | Gastrointestinal Parasites Immunoglobulin E Sheep immunoglobulin A MHC |
| url | http://hdl.handle.net/20.500.11937/18903 |