Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus?
© 2016 Springer Science+Business Media New York. Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress protective immune responses to non-tuberculous mycobacteria (NTM) and so potent...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Published: |
2016
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| Online Access: | http://hdl.handle.net/20.500.11937/18652 |
| _version_ | 1848749806512504832 |
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| author | Amran, F. Kim, K. Lim, A. Thomson, R. Lee, S. Waterer, G. Price, Patricia |
| author_facet | Amran, F. Kim, K. Lim, A. Thomson, R. Lee, S. Waterer, G. Price, Patricia |
| author_sort | Amran, F. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | © 2016 Springer Science+Business Media New York. Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress protective immune responses to non-tuberculous mycobacteria (NTM) and so potentiate pulmonary disease. Accordingly, levels of antibodies to three CMV antigen preparations were higher in NTM patients than in age-matched controls. This did not reflect broad-spectrum B cell activation as total immunoglobulin levels were not equivalently increased. |
| first_indexed | 2025-11-14T07:26:47Z |
| format | Journal Article |
| id | curtin-20.500.11937-18652 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:26:47Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-186522017-09-13T13:43:51Z Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus? Amran, F. Kim, K. Lim, A. Thomson, R. Lee, S. Waterer, G. Price, Patricia © 2016 Springer Science+Business Media New York. Cytomegalovirus (CMV) establishes lifelong infections with episodes of active replication. We hypothesized that recurrent CMV replication in older individuals may suppress protective immune responses to non-tuberculous mycobacteria (NTM) and so potentiate pulmonary disease. Accordingly, levels of antibodies to three CMV antigen preparations were higher in NTM patients than in age-matched controls. This did not reflect broad-spectrum B cell activation as total immunoglobulin levels were not equivalently increased. 2016 Journal Article http://hdl.handle.net/20.500.11937/18652 10.1007/s10875-016-0233-1 restricted |
| spellingShingle | Amran, F. Kim, K. Lim, A. Thomson, R. Lee, S. Waterer, G. Price, Patricia Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus? |
| title | Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus? |
| title_full | Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus? |
| title_fullStr | Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus? |
| title_full_unstemmed | Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus? |
| title_short | Is Pulmonary non-Tuberculous Mycobacterial Disease Linked with a High Burden of Latent Cytomegalovirus? |
| title_sort | is pulmonary non-tuberculous mycobacterial disease linked with a high burden of latent cytomegalovirus? |
| url | http://hdl.handle.net/20.500.11937/18652 |