A preliminary study on body plasma level of nitric oxide in workers exposed to carbon disulfide
OBJECTIVE: To study changes in body plasma level of nitric oxide (NO) in workers exposed to carbon disulfide (CS(2)) and its possible mechanism. METHODS: Plasma levels of NO and lipid peroxide (LPO) and activity of erythrocyte superoxide dismutase (Ery-SOD) were determined in the workers exposed and...
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| Format: | Journal Article |
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Chinese Medical Association
2000
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| Online Access: | http://hdl.handle.net/20.500.11937/18392 |
| _version_ | 1848749731948265472 |
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| author | Jiang, X. Jian, Le Hu, D. |
| author_facet | Jiang, X. Jian, Le Hu, D. |
| author_sort | Jiang, X. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | OBJECTIVE: To study changes in body plasma level of nitric oxide (NO) in workers exposed to carbon disulfide (CS(2)) and its possible mechanism. METHODS: Plasma levels of NO and lipid peroxide (LPO) and activity of erythrocyte superoxide dismutase (Ery-SOD) were determined in the workers exposed and unexposed to CS(2) in a chemical synthetic fiber works. RESULTS: Level of NO was (43.28 +/- 19.83) and (50.07 +/- 21.01) micromol/L in high- and low-dose exposed groups, respectively, significantly lower than that in the control group, which was (70.66 +/- 26.83) micromol/L (P < 0.05). Activity of Ery-SOD was 4 832.21 u/g Hb and 3,520.80 u/g Hb in high- and low-dose exposed groups, respectively, significantly higher than that in the control group, which was 2,425.34 u/g Hb (P < 0.05). Level of LPO was 19.38 and 17.09 micromol/L in high- and low-dose exposed groups, respectively, significantly higher than that in the control group, which was 4.37 micromol/L (P < 0.05). CONCLUSION: Occupational long-term exposure to CS(2) could induce reduction of NO level in the body with its mechanism related to increase of super-oxygen cation O(2)(*-) induced by CS(2). |
| first_indexed | 2025-11-14T07:25:36Z |
| format | Journal Article |
| id | curtin-20.500.11937-18392 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:25:36Z |
| publishDate | 2000 |
| publisher | Chinese Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-183922017-01-30T12:07:37Z A preliminary study on body plasma level of nitric oxide in workers exposed to carbon disulfide Jiang, X. Jian, Le Hu, D. Carbon disulfide nitric oxide lipid peroxides superoxide dismutase OBJECTIVE: To study changes in body plasma level of nitric oxide (NO) in workers exposed to carbon disulfide (CS(2)) and its possible mechanism. METHODS: Plasma levels of NO and lipid peroxide (LPO) and activity of erythrocyte superoxide dismutase (Ery-SOD) were determined in the workers exposed and unexposed to CS(2) in a chemical synthetic fiber works. RESULTS: Level of NO was (43.28 +/- 19.83) and (50.07 +/- 21.01) micromol/L in high- and low-dose exposed groups, respectively, significantly lower than that in the control group, which was (70.66 +/- 26.83) micromol/L (P < 0.05). Activity of Ery-SOD was 4 832.21 u/g Hb and 3,520.80 u/g Hb in high- and low-dose exposed groups, respectively, significantly higher than that in the control group, which was 2,425.34 u/g Hb (P < 0.05). Level of LPO was 19.38 and 17.09 micromol/L in high- and low-dose exposed groups, respectively, significantly higher than that in the control group, which was 4.37 micromol/L (P < 0.05). CONCLUSION: Occupational long-term exposure to CS(2) could induce reduction of NO level in the body with its mechanism related to increase of super-oxygen cation O(2)(*-) induced by CS(2). 2000 Journal Article http://hdl.handle.net/20.500.11937/18392 Chinese Medical Association restricted |
| spellingShingle | Carbon disulfide nitric oxide lipid peroxides superoxide dismutase Jiang, X. Jian, Le Hu, D. A preliminary study on body plasma level of nitric oxide in workers exposed to carbon disulfide |
| title | A preliminary study on body plasma level of nitric oxide in workers exposed to carbon disulfide |
| title_full | A preliminary study on body plasma level of nitric oxide in workers exposed to carbon disulfide |
| title_fullStr | A preliminary study on body plasma level of nitric oxide in workers exposed to carbon disulfide |
| title_full_unstemmed | A preliminary study on body plasma level of nitric oxide in workers exposed to carbon disulfide |
| title_short | A preliminary study on body plasma level of nitric oxide in workers exposed to carbon disulfide |
| title_sort | preliminary study on body plasma level of nitric oxide in workers exposed to carbon disulfide |
| topic | Carbon disulfide nitric oxide lipid peroxides superoxide dismutase |
| url | http://hdl.handle.net/20.500.11937/18392 |