The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the Western world. It is becoming increasingly clear that CRC is a diverse disease, as exemplified by the identification of subgroups of CRC tumours that are driven by distinct biology. Recently, a number of studies have...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Impact Journals
2015
|
| Online Access: | http://hdl.handle.net/20.500.11937/18387 |
| _version_ | 1848749730552610816 |
|---|---|
| author | Ong, C. Chong, P. McArt, D. Chan, J. Tan, H. Kumar, Alan Prem Chung, M. Clément, M. Soong, R. Van Schaeybroeck, S. Waugh, D. Johnston, P. Dunne, P. Salto-Tellez, M. |
| author_facet | Ong, C. Chong, P. McArt, D. Chan, J. Tan, H. Kumar, Alan Prem Chung, M. Clément, M. Soong, R. Van Schaeybroeck, S. Waugh, D. Johnston, P. Dunne, P. Salto-Tellez, M. |
| author_sort | Ong, C. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the Western world. It is becoming increasingly clear that CRC is a diverse disease, as exemplified by the identification of subgroups of CRC tumours that are driven by distinct biology. Recently, a number of studies have begun to define panels of diagnostically relevant markers to align patients into individual subgroups in an attempt to give information on prognosis and treatment response. We examined the immunohistochemical expression profile of 18 markers, each representing a putative role in cancer development, in 493 primary colorectal carcinomas using tissue microarrays. Through unsupervised clustering in stage II cancers, we identified two cluster groups that are broadly defined by inflammatory or immune-related factors (CD3, CD8, COX-2 and FOXP3) and stem-like factors (CD44, LGR5, SOX2, OCT4). The expression of the stem-like group markers was associated with a significantly worse prognosis compared to cases with lower expression. In addition, patients classified in the stem-like subgroup displayed a trend towards a benefit from adjuvant treatment. The biologically relevant and poor prognostic stem-like group could also be identified in early stage I cancers, suggesting a potential opportunity for the identification of aggressive tumors at a very early stage of the disease. |
| first_indexed | 2025-11-14T07:25:35Z |
| format | Journal Article |
| id | curtin-20.500.11937-18387 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:25:35Z |
| publishDate | 2015 |
| publisher | Impact Journals |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-183872017-01-30T12:07:36Z The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers Ong, C. Chong, P. McArt, D. Chan, J. Tan, H. Kumar, Alan Prem Chung, M. Clément, M. Soong, R. Van Schaeybroeck, S. Waugh, D. Johnston, P. Dunne, P. Salto-Tellez, M. Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the Western world. It is becoming increasingly clear that CRC is a diverse disease, as exemplified by the identification of subgroups of CRC tumours that are driven by distinct biology. Recently, a number of studies have begun to define panels of diagnostically relevant markers to align patients into individual subgroups in an attempt to give information on prognosis and treatment response. We examined the immunohistochemical expression profile of 18 markers, each representing a putative role in cancer development, in 493 primary colorectal carcinomas using tissue microarrays. Through unsupervised clustering in stage II cancers, we identified two cluster groups that are broadly defined by inflammatory or immune-related factors (CD3, CD8, COX-2 and FOXP3) and stem-like factors (CD44, LGR5, SOX2, OCT4). The expression of the stem-like group markers was associated with a significantly worse prognosis compared to cases with lower expression. In addition, patients classified in the stem-like subgroup displayed a trend towards a benefit from adjuvant treatment. The biologically relevant and poor prognostic stem-like group could also be identified in early stage I cancers, suggesting a potential opportunity for the identification of aggressive tumors at a very early stage of the disease. 2015 Journal Article http://hdl.handle.net/20.500.11937/18387 Impact Journals fulltext |
| spellingShingle | Ong, C. Chong, P. McArt, D. Chan, J. Tan, H. Kumar, Alan Prem Chung, M. Clément, M. Soong, R. Van Schaeybroeck, S. Waugh, D. Johnston, P. Dunne, P. Salto-Tellez, M. The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers |
| title | The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers |
| title_full | The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers |
| title_fullStr | The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers |
| title_full_unstemmed | The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers |
| title_short | The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers |
| title_sort | prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers |
| url | http://hdl.handle.net/20.500.11937/18387 |