Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic ß-cell dysfunction

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Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic ß-cell dysfunction

Various pancreatic ß-cell stressors including cytokines and saturated fatty acids are known to induce oxidative stress, which results in metabolic disturbances and a reduction in insulin secretion. However, the key mechanisms underlying dysfunction are unknown. We investigated the effects of prolong...

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Bibliographic Details
Main Authors:	Michalska, M., Wolf, G., Walther, R., Newsholme, Philip
Format:	Journal Article
Published:	2010
Online Access:	http://hdl.handle.net/20.500.11937/18255

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