The Effect of Diabetes and Hypertension on the Placental Permeation of the Hydrophilic Drug, Ranitidine

QR Code

The Effect of Diabetes and Hypertension on the Placental Permeation of the Hydrophilic Drug, Ranitidine

Introduction Ranitidine is a hydrophilic weak base and an H2-receptor antagonist which is commonly used for gastroesophageal reflux, including during pregnancy. It has limited placental permeation and can be used as a pre-anesthetic antacid to prevent aspiration of acidic stomach contents. Recent st...

Full description

Bibliographic Details
Main Authors:	Lalic-Popovic, M., Paunkovic, J., Grujic, Z., Golocorbin-Kon, S., Vasovic, V., Al-Salami, Hani, Mikov, M.
Format:	Journal Article
Published:	2016
Online Access:	http://hdl.handle.net/20.500.11937/18222

Similar Items

Diabetes and hypertension increase the placental and transcellular permeation of the lipophilic drug diazepam in pregnant women
by: Lalic-Popovic, M., et al.
Published: (2013)

Decreased placental and transcellular permeation of cefuroxime in pregnant women with diabetes
by: Lalic-Popovic, M., et al.
Published: (2015)

Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat
by: Lalic-Popovic, M., et al.
Published: (2013)

THE EFFECT OF BILE ACID SALT SODIUM 3ALPHA, 7ALPHA-DIHYDROXY-12-KETO-5BETA-CHOLANATE (MKC) AND PROBIOTIC PRETREATMENT ON GLICLAZIDE PERMEATION IN ILEAL TISSUES FROM HEALTHY AND DIABETIC RATS
by: Mikov, M., et al.
Published: (2014)

Correlation between in vitro tests for blood brain barrier penetration with in vivo gliclazide penetration
by: Lalic-Popovic, M., et al.
Published: (2013)

High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic Effect
by: Golocorbin-Kon, S., et al.
Published: (2017)

Probiotic pre-treatment reduces gliclazide permeation (ex vivo) in healthy rats but increases it in diabetic rats to the level seen in untreated healthy rats
by: Al-Salami, Hani, et al.
Published: (2008)

Lamotrigine and valproate pharmacokinetics interactions in epileptic patients
by: Lalic, M., et al.
Published: (2009)

Diabetes development increased concentrations of the conjugated bile acid, taurocholic acid in serum, while treatment with microencapsulated-taurocholic acid exerted no hypoglycaemic effects
by: Mathavan, S., et al.
Published: (2017)

Influence of the semisynthetic bile acid MKC on the ileal permeation of gliclazide in vitro in healthy and diabetic rats treated with probiotics
by: Al-Salami, Hani, et al.
Published: (2008)

An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations
by: Mooranian, A., et al.
Published: (2015)

Drug Permeation across the Blood-Brain Barrier: Applications of Nanotechnology
by: Fakhoury, M., et al.
Published: (2015)

Pharmacokinetic and Drug Absorption Profiles of the Anti-Hyperglycaemic Agent Gliclazide in Oral Tissue-Targeted Microcapsules in Rats
by: Jovic, Jelena, et al.
Published: (2020)

Gliclazide reduces MKC intestinal transport in healthy but not diabetic rats
by: Al-Salami, Hani, et al.
Published: (2009)

Probiotics decreased the bioavailability of the bile acid analog, monoketocholic acid, when coadministered with gliclazide, in healthy but not diabetic rats
by: Al-Salami, Hani, et al.
Published: (2012)

Dried Blood Spot: Utilizing Dry Blood For Pharmacokinetic Investigations—An Old Method with Great Future for Therapeutic Drug Monitoring
by: Maksimovic, V., et al.
Published: (2017)

Dried blood spot: Utilising dry blood for pharmacokinetic investigations - An old method with great future for therapeutic drug monitoring
by: Golocorbin-Kon, S., et al.
Published: (2018)

Application of bile acids in drug formulation and delivery
by: Stojancevic, M., et al.
Published: (2014)

NDMA formation by chloramination of ranitidine: Kinetics and mechanism
by: Roux, J., et al.
Published: (2012)

Novel chenodeoxycholic acid-sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study
by: Mooranian, A., et al.
Published: (2015)

The Role of Drug Metabolites in the Inhibition of Cytochrome P450 Enzymes
by: Mikov, M., et al.
Published: (2017)

Bile acids and their derivatives as potential modifiers of drug release and pharmacokinetic profiles
by: Pavlovic, N., et al.
Published: (2018)

Probiotics applications in autoimmune diseases
by: Al-Salami, Hani, et al.
Published: (2012)

Potential Applications of Gliclazide in Treating Type 1 Diabetes Mellitus: Formulation with Bile Acids and Probiotics
by: Mikov, M., et al.
Published: (2017)

Insights regarding drug permeation into skin
by: AL-Mayahy, Mohammed Hussain Neama
Published: (2017)

Maternal body weight and gestational diabetes differentially influence placental and pregnancy outcomes
by: Martino, J., et al.
Published: (2015)

Stability and Release Kinetics of an Advanced Gliclazide-Cholic Acid Formulation: The Use of Artificial-Cell Microencapsulation in Slow Release Targeted Oral Delivery of Antidiabetics
by: Mooranian, Armin, et al.
Published: (2014)

Bile acids and probiotics could help treating diabetes
by: Calasan, J., et al.
Published: (2012)

Release and swelling studies of an innovative antidiabetic-bile acid microencapsulated formulation, as a novel targeted therapy for diabetes treatment
by: Mooranian, Armin, et al.
Published: (2015)

An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques
by: Mooranian, Armin, et al.
Published: (2019)

Enhanced toxicity and antifungal effects of iron-oxide chitosan/samarium/ranitidine microparticles
by: Kusrini, Eny, et al.
Published: (2025)

Improvement of Drug Release and Compatibility between Hydrophilic Drugs and Hydrophobic Nanofibrous Composites
by: Haroosh, Hazim, et al.
Published: (2021)

Evaluation of different extraction method for the isolation of cimetidine and ranitidine from human plasma for HPLC analysis
by: Helal Uddin, A.B.M., et al.
Published: (2012)

Pharmacological effects of nanoencapsulation of human-based dosing of probucol on ratio of secondary to primary bile acids in gut, during induction and progression of type 1 diabetes
by: Mooranian, Armin, et al.
Published: (2018)

Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation
by: Eisele, Nicole, et al.
Published: (2016)

The Influence of Intestinal Tract and Probiotics on the Fate of Orally Administered Drugs
by: Stojancevic, M., et al.
Published: (2013)

Pharmacological Applications of Bile Acids and Their Derivatives in the Treatment of Metabolic Syndrome
by: Danic, M., et al.
Published: (2018)

Eudragit®-based microcapsules of probucol with a gut-bacterial processed secondary bile acid
by: Mooranian, A., et al.
Published: (2018)

Novel nano-encapsulation of probucol in microgels: scanning electron micrograph characterizations, buoyancy profiling, and antioxidant assay analyses
by: Mooranian, A., et al.
Published: (2018)

Metabolic alterations induced by high maternal BMI and gestational diabetes in maternal, placental and neonatal outcomes
by: Martino, Jole
Published: (2013)