Alternatively spliced isoforms of tissue factor pathway inhibitor
Tissue factor pathway inhibitor (TFPI) is the major regulator of tissue factor (TF)-induced coagulation. It down regulates coagulation by binding to the TF/fVIIa complex in a fXa dependent manner. It is predominantly produced by microvascular endothelial cells, though it is also found in platelets,...
| Main Authors: | , , |
|---|---|
| Format: | Journal Article |
| Published: |
Pergamon
2010
|
| Online Access: | http://hdl.handle.net/20.500.11937/18159 |
| _version_ | 1848749665231568896 |
|---|---|
| author | Maroney, S. Ellery, Paul Mast, A. |
| author_facet | Maroney, S. Ellery, Paul Mast, A. |
| author_sort | Maroney, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Tissue factor pathway inhibitor (TFPI) is the major regulator of tissue factor (TF)-induced coagulation. It down regulates coagulation by binding to the TF/fVIIa complex in a fXa dependent manner. It is predominantly produced by microvascular endothelial cells, though it is also found in platelets, monocytes, smooth muscle cells, and plasma. Its physiological importance is demonstrated by the embryonic lethality observed in TFPI knockout mice and by the increase in thrombotic burden that occurs when heterozygous TFPI mice are bred with mice carrying genetic risk factors for thrombotic disease, such as factor V Leiden. Multiple TFPI isoforms, termed TFPIa, TFPIß, and TFPId in humans and TFPIa, TFPIß, and TFPI? in mice, have been described, which differ in their domain structure and method for cell surface attachment. A significant functional difference between these isoforms has yet to be described in vivo. Both human and mouse tissues produce, on average, approximately 10 times more TFPIa message when compared to that of TFPIß. Consistent with this finding, several lines of evidence suggest that TFPIa is the predominant protein isoform in humans. In contrast, recent work from our laboratory demonstrates that TFPIß is the major protein isoform produced in adult mice, suggesting that TFPI isoform production is translationally regulated. © 2010 Elsevier Ltd. All rights reserved. |
| first_indexed | 2025-11-14T07:24:33Z |
| format | Journal Article |
| id | curtin-20.500.11937-18159 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:24:33Z |
| publishDate | 2010 |
| publisher | Pergamon |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-181592018-03-29T09:06:20Z Alternatively spliced isoforms of tissue factor pathway inhibitor Maroney, S. Ellery, Paul Mast, A. Tissue factor pathway inhibitor (TFPI) is the major regulator of tissue factor (TF)-induced coagulation. It down regulates coagulation by binding to the TF/fVIIa complex in a fXa dependent manner. It is predominantly produced by microvascular endothelial cells, though it is also found in platelets, monocytes, smooth muscle cells, and plasma. Its physiological importance is demonstrated by the embryonic lethality observed in TFPI knockout mice and by the increase in thrombotic burden that occurs when heterozygous TFPI mice are bred with mice carrying genetic risk factors for thrombotic disease, such as factor V Leiden. Multiple TFPI isoforms, termed TFPIa, TFPIß, and TFPId in humans and TFPIa, TFPIß, and TFPI? in mice, have been described, which differ in their domain structure and method for cell surface attachment. A significant functional difference between these isoforms has yet to be described in vivo. Both human and mouse tissues produce, on average, approximately 10 times more TFPIa message when compared to that of TFPIß. Consistent with this finding, several lines of evidence suggest that TFPIa is the predominant protein isoform in humans. In contrast, recent work from our laboratory demonstrates that TFPIß is the major protein isoform produced in adult mice, suggesting that TFPI isoform production is translationally regulated. © 2010 Elsevier Ltd. All rights reserved. 2010 Journal Article http://hdl.handle.net/20.500.11937/18159 10.1016/j.thromres.2010.01.038 Pergamon restricted |
| spellingShingle | Maroney, S. Ellery, Paul Mast, A. Alternatively spliced isoforms of tissue factor pathway inhibitor |
| title | Alternatively spliced isoforms of tissue factor pathway inhibitor |
| title_full | Alternatively spliced isoforms of tissue factor pathway inhibitor |
| title_fullStr | Alternatively spliced isoforms of tissue factor pathway inhibitor |
| title_full_unstemmed | Alternatively spliced isoforms of tissue factor pathway inhibitor |
| title_short | Alternatively spliced isoforms of tissue factor pathway inhibitor |
| title_sort | alternatively spliced isoforms of tissue factor pathway inhibitor |
| url | http://hdl.handle.net/20.500.11937/18159 |