The human papillomavirus Test of Cure: A lesson on compliance with the NHMRC guidelines on screening to prevent cervical cancer
Background - In Australia, high-risk human papillomavirus (HR HPV) testing is recommended for follow-up of women treated for a high-grade squamous intra-epithelial lesion (HSIL). The sensitivity of HR HPV testing is critical to identify women at risk of further high-grade cervical disease. In Austra...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
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Wiley-Blackwell Publishing Asia
2015
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/18154 |
| _version_ | 1848749663800262656 |
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| author | Munro, A. Spilsbury, Katrina Leung, Y. O'Leary, Peter Williams, Vincent Codde, J. Steel, N. Cohen, P. Semmens, James |
| author_facet | Munro, A. Spilsbury, Katrina Leung, Y. O'Leary, Peter Williams, Vincent Codde, J. Steel, N. Cohen, P. Semmens, James |
| author_sort | Munro, A. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background - In Australia, high-risk human papillomavirus (HR HPV) testing is recommended for follow-up of women treated for a high-grade squamous intra-epithelial lesion (HSIL). The sensitivity of HR HPV testing is critical to identify women at risk of further high-grade cervical disease. In Australia, this management protocol is known as the ‘Test of Cure’ (ToC). Aim - To conduct a population-based study investigating practitioners' compliance with ToC. Materials and Methods - Women treated for an HSIL between the five-year period 01 Jan 2006 to 31 Dec 2010 were identified and followed up for at least a 27-month period. Proportions and relative odds were determined for women entering and completing the ToC management pathway within recommended time frames. Results - There were 5,194 women identified as ‘eligible’ to enter the ToC management pathway. Of these, 1,916 (37%) were managed with annual Pap smears and never had a HR HPV test performed. There were 1,296 (25%) women who entered the ToC management pathway within recommended time frames, and a further 1,978 (38%) women entered outside of the recommended time frames. Overall, 961 women completed the ToC and were classified as ‘cured’ and were eligible to return to two-yearly Pap smears. Women's demographic information was significantly associated with ToC commencement, specifically, age and year of treatment, and Index of Relative Socioeconomic Disadvantage. Conclusion - Overall, a significant number of Australian women did not enter (~37%) and complete (~50%) the ToC management pathway. The challenge remains to advocate its use to practitioners to ensure women are returned to the population screening interval in a timely manner. |
| first_indexed | 2025-11-14T07:24:31Z |
| format | Journal Article |
| id | curtin-20.500.11937-18154 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:24:31Z |
| publishDate | 2015 |
| publisher | Wiley-Blackwell Publishing Asia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-181542017-09-13T13:44:34Z The human papillomavirus Test of Cure: A lesson on compliance with the NHMRC guidelines on screening to prevent cervical cancer Munro, A. Spilsbury, Katrina Leung, Y. O'Leary, Peter Williams, Vincent Codde, J. Steel, N. Cohen, P. Semmens, James high-grade squamous intra-epithelial lesion cervical management Background - In Australia, high-risk human papillomavirus (HR HPV) testing is recommended for follow-up of women treated for a high-grade squamous intra-epithelial lesion (HSIL). The sensitivity of HR HPV testing is critical to identify women at risk of further high-grade cervical disease. In Australia, this management protocol is known as the ‘Test of Cure’ (ToC). Aim - To conduct a population-based study investigating practitioners' compliance with ToC. Materials and Methods - Women treated for an HSIL between the five-year period 01 Jan 2006 to 31 Dec 2010 were identified and followed up for at least a 27-month period. Proportions and relative odds were determined for women entering and completing the ToC management pathway within recommended time frames. Results - There were 5,194 women identified as ‘eligible’ to enter the ToC management pathway. Of these, 1,916 (37%) were managed with annual Pap smears and never had a HR HPV test performed. There were 1,296 (25%) women who entered the ToC management pathway within recommended time frames, and a further 1,978 (38%) women entered outside of the recommended time frames. Overall, 961 women completed the ToC and were classified as ‘cured’ and were eligible to return to two-yearly Pap smears. Women's demographic information was significantly associated with ToC commencement, specifically, age and year of treatment, and Index of Relative Socioeconomic Disadvantage. Conclusion - Overall, a significant number of Australian women did not enter (~37%) and complete (~50%) the ToC management pathway. The challenge remains to advocate its use to practitioners to ensure women are returned to the population screening interval in a timely manner. 2015 Journal Article http://hdl.handle.net/20.500.11937/18154 10.1111/ajo.12309 Wiley-Blackwell Publishing Asia unknown |
| spellingShingle | high-grade squamous intra-epithelial lesion cervical management Munro, A. Spilsbury, Katrina Leung, Y. O'Leary, Peter Williams, Vincent Codde, J. Steel, N. Cohen, P. Semmens, James The human papillomavirus Test of Cure: A lesson on compliance with the NHMRC guidelines on screening to prevent cervical cancer |
| title | The human papillomavirus Test of Cure: A lesson on compliance with the NHMRC guidelines on screening to prevent cervical cancer |
| title_full | The human papillomavirus Test of Cure: A lesson on compliance with the NHMRC guidelines on screening to prevent cervical cancer |
| title_fullStr | The human papillomavirus Test of Cure: A lesson on compliance with the NHMRC guidelines on screening to prevent cervical cancer |
| title_full_unstemmed | The human papillomavirus Test of Cure: A lesson on compliance with the NHMRC guidelines on screening to prevent cervical cancer |
| title_short | The human papillomavirus Test of Cure: A lesson on compliance with the NHMRC guidelines on screening to prevent cervical cancer |
| title_sort | human papillomavirus test of cure: a lesson on compliance with the nhmrc guidelines on screening to prevent cervical cancer |
| topic | high-grade squamous intra-epithelial lesion cervical management |
| url | http://hdl.handle.net/20.500.11937/18154 |