Albumin domain II mutant with high bilirubin binding affinity has a great potential as serum bilirubin excretion enhancer for hyperbilirubinemia treatment

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Albumin domain II mutant with high bilirubin binding affinity has a great potential as serum bilirubin excretion enhancer for hyperbilirubinemia treatment

Background: 4Z,15Z-bilirubin-IXα (BR), an endogenous toxic compound that is sparingly soluble in water, binds human serum albumin (HSA) with high affinity in a flexible manner. Our previous findings suggest that both Lys195 and Lys199 in subdomain IIA are important for the high-affinity binding of B...

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Bibliographic Details
Main Authors:	Minomo, Ai, Ishima, Yu, Chuang, Victor, Suwa, Yoshiaki, Kragh-Hansen, Ulrich, Narisoko, Toru, Morioka, Hiroshi, Maruyama, Toru, Otagiri, Masaki
Format:	Journal Article
Published:	Elsevier BV 2013
Online Access:	http://hdl.handle.net/20.500.11937/18060

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