Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy

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Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy

A novel series of sigma (s) receptor ligands based on an alkoxyisoxazole scaffold has been designed and synthesized. Preliminary receptor binding assays identified highly potent (Ki < 1 nM) and selective s1 ligands devoid of binding interactions with the monoamine transporters DAT, NET, and SERT....

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Bibliographic Details
Main Authors:	Sun, H., Shi, M., Zhang, W., Zheng, Y., Xu, Y., Shi, J., Liu, T., Gunosewoyo, Hendra, Pang, T., Gao, Z., Yang, F., Tang, J., Yu, L.
Format:	Journal Article
Published:	American Chemical Society 2016
Online Access:	http://hdl.handle.net/20.500.11937/18018

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