Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy
Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and &#...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
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2009
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| Online Access: | http://hdl.handle.net/20.500.11937/17997 |
| _version_ | 1848749618941132800 |
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| author | Zhang, Guicheng Khoo, S. Laatikainen, T. Pekkarinen, P. Vartiainen, E. Von Hertzen, L. Hayden, C. Goldblatt, J. Mäkelä, M. Haahtela, T. Le Souëf, P. |
| author_facet | Zhang, Guicheng Khoo, S. Laatikainen, T. Pekkarinen, P. Vartiainen, E. Von Hertzen, L. Hayden, C. Goldblatt, J. Mäkelä, M. Haahtela, T. Le Souëf, P. |
| author_sort | Zhang, Guicheng |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments. Objectives: We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Methods: Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. Results: For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash <12 mo (P interaction = 0.001) and dry cough at night in the past 12 months (<12 months) (Pinteraction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (Pinteraction = 0.006), rhinitis <12 mo (P interaction = 0.004), and marginally significant for ever hayfever (Pinteraction = 0.07), allergic eye symptoms <12 mo (P interaction = 0.09); their risk allele was G in Russians and A in Finns. Conclusion: An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. © 2009 John Wiley & Sons A/S. |
| first_indexed | 2025-11-14T07:23:48Z |
| format | Journal Article |
| id | curtin-20.500.11937-17997 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:23:48Z |
| publishDate | 2009 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-179972017-09-13T15:42:21Z Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy Zhang, Guicheng Khoo, S. Laatikainen, T. Pekkarinen, P. Vartiainen, E. Von Hertzen, L. Hayden, C. Goldblatt, J. Mäkelä, M. Haahtela, T. Le Souëf, P. Background: Finnish Karelians have a higher prevalence of allergic disease than Russian Karelians. As both populations are generally from the same ethnic group, the Karelian population offers a unique opportunity to analyse genetic and allergic disease interactions between 'Western' and 'Eastern' environments. Objectives: We investigated associations between allergic diseases and CD14 and CC16 polymorphisms in Finnish vs Russian Karelian women. Methods: Adult female Karelians (330 Finnish and 274 Russian) were recruited, examined for a range of symptoms and conditions including rhinitis, itchy rash, asthma and atopy and genotyped for CD14 C-159T and CC16 A38G. Results: For both CD14 C-159T and CC16 A38G, the risk allele for atopic phenotypes in Finnish Karelia was the protective allele in Russian Karelia. For CD14 C-159T, an interactive effect on ever itchy rash (Pinteraction = 0.004), itchy rash <12 mo (P interaction = 0.001) and dry cough at night in the past 12 months (<12 months) (Pinteraction = 0.011) was found; the risk allele was C in Russians and T in Finns. For CC16 A38G, an interaction was significant for ever rhinitis (Pinteraction = 0.006), rhinitis <12 mo (P interaction = 0.004), and marginally significant for ever hayfever (Pinteraction = 0.07), allergic eye symptoms <12 mo (P interaction = 0.09); their risk allele was G in Russians and A in Finns. Conclusion: An Eastern vs Western environment appears to exert an effect via opposite alleles on risk of allergic diseases in adult women. © 2009 John Wiley & Sons A/S. 2009 Journal Article http://hdl.handle.net/20.500.11937/17997 10.1111/j.1398-9995.2009.02006.x restricted |
| spellingShingle | Zhang, Guicheng Khoo, S. Laatikainen, T. Pekkarinen, P. Vartiainen, E. Von Hertzen, L. Hayden, C. Goldblatt, J. Mäkelä, M. Haahtela, T. Le Souëf, P. Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy |
| title | Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy |
| title_full | Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy |
| title_fullStr | Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy |
| title_full_unstemmed | Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy |
| title_short | Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy |
| title_sort | opposite gene by environment interactions in karelia for cd14 and cc16 single nucleotide polymorphisms and allergy |
| url | http://hdl.handle.net/20.500.11937/17997 |