A Rapid Test for Heroin (3,6-Diacetylmorphine) Based on Two Chemiluminescence Reactions
A rapid method for screening drug seizure samples for 3,6-diacetylmorphine (heroin), which consists of a simple hydrolysis procedure and flow-injection analysis with two chemiluminescence reagents, is described. Before hydrolysis, 3,6-diacetylmorphine evokes an intense response with a tris(2,20-bipy...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Blackwell Publishing
2006
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/17815 |
| _version_ | 1848749566376017920 |
|---|---|
| author | Agg, K. Craddock, A. Bos, R. Francis, P. Lewis, Simon Barnett, N. |
| author_facet | Agg, K. Craddock, A. Bos, R. Francis, P. Lewis, Simon Barnett, N. |
| author_sort | Agg, K. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | A rapid method for screening drug seizure samples for 3,6-diacetylmorphine (heroin), which consists of a simple hydrolysis procedure and flow-injection analysis with two chemiluminescence reagents, is described. Before hydrolysis, 3,6-diacetylmorphine evokes an intense response with a tris(2,20-bipyridyl)ruthenium(III) reagent (prepared by dissolving the perchlorate salt in acetonitrile), and a relatively weak chemiluminescence response with a second reagent: potassium permanganate in an aqueous acidic polyphosphate solution. However, the permanganate reagent is extremely sensitive toward the hydrolysis products of 3,6-diacetylmorphine (i.e., 6-monoacetylmorphine and morphine). Some compounds commonly found in drug laboratories may cause false positives with tris(2,20-bipyridyl)ruthenium(III), but do not produce the markedly increased response with the permanganate reagent after the hydrolysis procedure. The combination of these two tests therefore provides an effective presumptive test for the presence of 3,6-diacetylmorphine, which we have verified with 14 samples obtained from a forensic science laboratory. |
| first_indexed | 2025-11-14T07:22:58Z |
| format | Journal Article |
| id | curtin-20.500.11937-17815 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T07:22:58Z |
| publishDate | 2006 |
| publisher | Blackwell Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-178152018-10-01T04:21:40Z A Rapid Test for Heroin (3,6-Diacetylmorphine) Based on Two Chemiluminescence Reactions Agg, K. Craddock, A. Bos, R. Francis, P. Lewis, Simon Barnett, N. chemiluminescence spot test presumptive chemical test forensic science drug screening 3 morphine 6-diacetylmorphine forensic chemistry heroin A rapid method for screening drug seizure samples for 3,6-diacetylmorphine (heroin), which consists of a simple hydrolysis procedure and flow-injection analysis with two chemiluminescence reagents, is described. Before hydrolysis, 3,6-diacetylmorphine evokes an intense response with a tris(2,20-bipyridyl)ruthenium(III) reagent (prepared by dissolving the perchlorate salt in acetonitrile), and a relatively weak chemiluminescence response with a second reagent: potassium permanganate in an aqueous acidic polyphosphate solution. However, the permanganate reagent is extremely sensitive toward the hydrolysis products of 3,6-diacetylmorphine (i.e., 6-monoacetylmorphine and morphine). Some compounds commonly found in drug laboratories may cause false positives with tris(2,20-bipyridyl)ruthenium(III), but do not produce the markedly increased response with the permanganate reagent after the hydrolysis procedure. The combination of these two tests therefore provides an effective presumptive test for the presence of 3,6-diacetylmorphine, which we have verified with 14 samples obtained from a forensic science laboratory. 2006 Journal Article http://hdl.handle.net/20.500.11937/17815 10.1111/j.1556-4029.2006.00215.x Blackwell Publishing restricted |
| spellingShingle | chemiluminescence spot test presumptive chemical test forensic science drug screening 3 morphine 6-diacetylmorphine forensic chemistry heroin Agg, K. Craddock, A. Bos, R. Francis, P. Lewis, Simon Barnett, N. A Rapid Test for Heroin (3,6-Diacetylmorphine) Based on Two Chemiluminescence Reactions |
| title | A Rapid Test for Heroin (3,6-Diacetylmorphine) Based on Two Chemiluminescence Reactions |
| title_full | A Rapid Test for Heroin (3,6-Diacetylmorphine) Based on Two Chemiluminescence Reactions |
| title_fullStr | A Rapid Test for Heroin (3,6-Diacetylmorphine) Based on Two Chemiluminescence Reactions |
| title_full_unstemmed | A Rapid Test for Heroin (3,6-Diacetylmorphine) Based on Two Chemiluminescence Reactions |
| title_short | A Rapid Test for Heroin (3,6-Diacetylmorphine) Based on Two Chemiluminescence Reactions |
| title_sort | rapid test for heroin (3,6-diacetylmorphine) based on two chemiluminescence reactions |
| topic | chemiluminescence spot test presumptive chemical test forensic science drug screening 3 morphine 6-diacetylmorphine forensic chemistry heroin |
| url | http://hdl.handle.net/20.500.11937/17815 |