Inhibition of P-glycoprotein - Mediated Efflux of Digoxinand Its Metabolites by Macrolide Antibiotics

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Inhibition of P-glycoprotein - Mediated Efflux of Digoxinand Its Metabolites by Macrolide Antibiotics

This study was conducted to determine the rate of P-glycoprotein (P-gp) mediated efflux of digoxin analogues and metabolites, and to assess the effects of macrolide antibiotics on this efflux. Bidirectional transport studies were conducted using our Caco-2 sub clone with high P-gp expression (CLEFF9...

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Bibliographic Details
Main Authors:	Hughes, Jeffery, Crowe, Andrew
Other Authors:	Kim Brosen
Format:	Journal Article
Published:	The Japanese Pharmacological Society 2010
Subjects:	clarithromycin Caco-2 P-glycoprotein erythromycin azithromycin
Online Access:	http://hdl.handle.net/20.500.11937/17778

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