The influence of passage number for Caco2 cell models when evaluating P-gp mediated drug transport

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The influence of passage number for Caco2 cell models when evaluating P-gp mediated drug transport

Caco2 cells are a human adenocarcinoma cell line that forms tight junctions and are widely used to examine bidirectional drug transport as well as P-glycoprotein mediated efflux. Unfortunately Caco2 cell lines can be very heterogeneous in nature. Our aim was to improve the Caco2 cell model for deter...

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Bibliographic Details
Main Authors:	Senarathna, Ganga, Crowe, Andrew
Format:	Journal Article
Published:	2015
Online Access:	http://hdl.handle.net/20.500.11937/17645

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