Is there potential for repurposing statins as novel antimicrobials?
Copyright © 2016, American Society for Microbiology. All Rights Reserved.Statins are members of a class of pharmaceutical widely used to reduce high levels of serum cholesterol. In addition, statins have so-called "pleiotropic effects," which include inflammation reduction, immunomodulatio...
| Main Authors: | Hennessy, E., Adams, C., Reen, F., O'Gara, Fergal |
|---|---|
| Format: | Journal Article |
| Published: |
American Society for Microbiology
2016
|
| Online Access: | http://hdl.handle.net/20.500.11937/17526 |
Similar Items
Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa
by: Hennessey, E., et al.
Published: (2013)
by: Hennessey, E., et al.
Published: (2013)
Marine pseudovibrio sp. as a novel source of antimicrobials
by: Crowley, S., et al.
Published: (2014)
by: Crowley, S., et al.
Published: (2014)
Subinhibitory concentrations of the cationic antimicrobial peptide colistin induce the pseudomonas quinolone signal in Pseudomonas aeruginosa
by: Cummins, J., et al.
Published: (2009)
by: Cummins, J., et al.
Published: (2009)
Low oxygen induces the type III secretion system in Pseudomonas aeruginosa via modulation of the small RNAs rsmZ and rsmY
by: O'Callaghan, J., et al.
Published: (2011)
by: O'Callaghan, J., et al.
Published: (2011)
A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa-host cell interactions
by: O'Callaghan, J., et al.
Published: (2012)
by: O'Callaghan, J., et al.
Published: (2012)
Tle distribution and diversity in metagenomic datasets reveal niche specialization
by: Egan, F., et al.
Published: (2015)
by: Egan, F., et al.
Published: (2015)
Statins: Antimicrobial resistance breakers or makers?
by: Ko, H., et al.
Published: (2017)
by: Ko, H., et al.
Published: (2017)
Respiratory Pathogens Adopt a Chronic Lifestyle in Response to Bile
by: Reen, F., et al.
Published: (2012)
by: Reen, F., et al.
Published: (2012)
Mining Microbial Signals for Enhanced Biodiscovery of Secondary Metabolites
by: Reen, F., et al.
Published: (2017)
by: Reen, F., et al.
Published: (2017)
The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes
by: Reen, F., et al.
Published: (2018)
by: Reen, F., et al.
Published: (2018)
The sound of silence: Activating silent biosynthetic gene clusters in marine microorganisms
by: Reen, F., et al.
Published: (2015)
by: Reen, F., et al.
Published: (2015)
Emerging concepts promising new horizons for marine biodiscovery and synthetic biology
by: Reen, F., et al.
Published: (2015)
by: Reen, F., et al.
Published: (2015)
Identification of secondary metabolite gene clusters in the Pseudovibrio Genus reveals encouraging biosynthetic potential toward the production of novel bioactive compounds
by: Naughton, L., et al.
Published: (2017)
by: Naughton, L., et al.
Published: (2017)
Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism.
by: Caparrós-Martín, J., et al.
Published: (2017)
by: Caparrós-Martín, J., et al.
Published: (2017)
Bile Acids Repress Hypoxia-Inducible Factor 1 Signaling and Modulate the Airway Immune Response
by: Legendre, C., et al.
Published: (2014)
by: Legendre, C., et al.
Published: (2014)
Deciphering the role of coumarin as a novel quorum sensing inhibitor suppressing virulence phenotypes in bacterial pathogens
by: Gutiérrez-Barranquero, J., et al.
Published: (2015)
by: Gutiérrez-Barranquero, J., et al.
Published: (2015)
Harnessing Marine Biocatalytic Reservoirs for Green Chemistry Applications through Metagenomic Technologies
by: Castilla, I., et al.
Published: (2018)
by: Castilla, I., et al.
Published: (2018)
A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa.
by: Reen, F, et al.
Published: (2013)
by: Reen, F, et al.
Published: (2013)
Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections
by: Ó Muimhneacháin, E., et al.
Published: (2018)
by: Ó Muimhneacháin, E., et al.
Published: (2018)
Pseudomonas aeruginosa Alkyl quinolones repress hypoxia-inducible factor 1 (HIF-1) signaling through HIF-1a degradation
by: Legendre, C., et al.
Published: (2012)
by: Legendre, C., et al.
Published: (2012)
Erratum to: Deciphering the role of coumarin as a novel quorum sensing inhibitor suppressing virulence phenotypes in bacterial pathogens [Appl Microbiol Biotechnol, 10.1007/s00253-015-6436-1]
by: Gutiérrez-Barranquero, J., et al.
Published: (2015)
by: Gutiérrez-Barranquero, J., et al.
Published: (2015)
Molecular evolution of LysR-type transcriptional regulation in Pseudomonas aeruginosa
by: Reen, F., et al.
Published: (2013)
by: Reen, F., et al.
Published: (2013)
Transcriptome profiling defines a novel regulon modulated by the LysR-type transcriptional regulator MexT in Pseudomonas aeruginosa
by: Tian, Z., et al.
Published: (2009)
by: Tian, Z., et al.
Published: (2009)
Tackling antimicrobial resistance through two novel methods: repurposing vanoxerine as a novel anti-tubercular drug; and silencing virulence in Pseudomonas aeruginosa through inhibition of PqsR
by: Grossman, Scott
Published: (2018)
by: Grossman, Scott
Published: (2018)
Translational research for chronic respiratory disease: intercepting the bile aspiration paradigm
by: Reen, F., et al.
Published: (2014)
by: Reen, F., et al.
Published: (2014)
Intercepting the Bile Aspiration Paradigm: Innovative Intervention for Chronic Respiratory Disease
by: Reen, F., et al.
Published: (2015)
by: Reen, F., et al.
Published: (2015)
Impaired expression of hypoxia-inducible factor-1a in cystic fibrosis airway epithelial cells - A role for HIF-1 in the pathophysiology of CF?
by: Legendre, C., et al.
Published: (2011)
by: Legendre, C., et al.
Published: (2011)
Genomic analysis of the type VI secretion systems in Pseudomonas spp.: Novel clusters and putative effectors uncovered
by: Barret, M., et al.
Published: (2011)
by: Barret, M., et al.
Published: (2011)
Inhibition of co-colonizing cystic fibrosis-associated pathogens by Pseudomonas aeruginosa and Burkholderia multivorans
by: Costello, A., et al.
Published: (2014)
by: Costello, A., et al.
Published: (2014)
The Impact of Simvastatin on Pulmonary Effectors of Pseudomonas aeruginosa Infection
by: Hennessy, E., et al.
Published: (2014)
by: Hennessy, E., et al.
Published: (2014)
Bile acids destabilise HIF-1a and promote anti-tumour phenotypes in cancer cell models.
by: Phelan, J., et al.
Published: (2016)
by: Phelan, J., et al.
Published: (2016)
A new regulator of pathogenicity (bvlR) is required for full virulence and tight microcolony formation in Pseudomonas aeruginosa
by: McCarthy, R., et al.
Published: (2014)
by: McCarthy, R., et al.
Published: (2014)
A Novel Erythromycin Resistance Plasmid from Bacillus Sp. Strain HS24, Isolated from the Marine Sponge Haliclona Simulans
by: Barbosa, T., et al.
Published: (2014)
by: Barbosa, T., et al.
Published: (2014)
Integrated (Meta) genomic and synthetic biology approaches to develop new biocatalysts
by: Parages, M., et al.
Published: (2016)
by: Parages, M., et al.
Published: (2016)
Synthesis of Benzofuroquinolines via Phosphine-Free Direct Arylation of 4-Phenoxyquinolines in Air
by: Shanahan, R., et al.
Published: (2018)
by: Shanahan, R., et al.
Published: (2018)
Genome Sequence of Paracoccus sp. JM45, a Bacterial Strain Isolated from a Marine Sponge with a Dual Quorum Sensing Inhibition Activity.
by: Gutiérrez-Barranquero, J., et al.
Published: (2019)
by: Gutiérrez-Barranquero, J., et al.
Published: (2019)
The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa
by: Shanahan, R., et al.
Published: (2017)
by: Shanahan, R., et al.
Published: (2017)
A structure activity-relationship study of the bacterial signal molecule HHQ reveals swarming motility inhibition in Bacillus atrophaeus
by: Reen, F., et al.
Published: (2015)
by: Reen, F., et al.
Published: (2015)
Rethinking the bile acid/gut microbiome axis in cancer
by: Phelan, J., et al.
Published: (2017)
by: Phelan, J., et al.
Published: (2017)
Bile signalling promotes chronic respiratory infections and antibiotic tolerance
by: Reen, F., et al.
Published: (2016)
by: Reen, F., et al.
Published: (2016)
Similar Items
-
Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa
by: Hennessey, E., et al.
Published: (2013) -
Marine pseudovibrio sp. as a novel source of antimicrobials
by: Crowley, S., et al.
Published: (2014) -
Subinhibitory concentrations of the cationic antimicrobial peptide colistin induce the pseudomonas quinolone signal in Pseudomonas aeruginosa
by: Cummins, J., et al.
Published: (2009) -
Low oxygen induces the type III secretion system in Pseudomonas aeruginosa via modulation of the small RNAs rsmZ and rsmY
by: O'Callaghan, J., et al.
Published: (2011) -
A novel host-responsive sensor mediates virulence and type III secretion during Pseudomonas aeruginosa-host cell interactions
by: O'Callaghan, J., et al.
Published: (2012)